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  1. Vor 9 Stunden · Finally, our study did not capture treatment-associated comorbidities and patient preferences that may have been shaped by these adverse effects. Cisplatin-based NAC is not without potential significant adverse effects, notably irreversible nephrotoxicity, cumulative peripheral neuropathy, ototoxicity, as well as myelosuppression.

  2. Vor 9 Stunden · Effects of climate change. Some climate change effects: wildfire caused by heat and dryness, bleached coral caused by ocean acidification and heating, environmental migration caused by desertification, and coastal flooding caused by storms and sea level rise. Effects of climate change are well documented and growing for Earth's natural ...

  3. Vor 9 Stunden · There is a big gap in our knowledge about how HIV infection leads to this very slow CD4 depletion, over many years, rather than any immediate dramatic irreversible loss of any CD4 T cell subset during primary infection – some of the typical initial CD4 loss appears to result from extravasation due to significant inflammation in lymphoid tissue, and so has to be carefully interpreted, as ...

  4. Vor 9 Stunden · To explore this issue, I first contrast the Commission's definition of efficiencies with the commercial concept of synergies, or wider deal rationale. This explains some of the divide between the commercial and regulatory view of merger benefits and provides context for further analyses. I then summarise my findings from these analyses at a high level, and in subsequent sections provide more ...

  5. Vor 9 Stunden · irreversible mechanisms. To focus on the irreversibility contributions appear-ing at different timescales, it is useful to define the ir-reversibility associated with slices of trajectories with length tas D(t). In the simplest case of trajectories with independent increments, irreversibility increases with a constant rate,

  6. Vor 9 Stunden · The Interpretation Act 1987 contains definitions and other provisions that afect the interpretation and application of this Act. (1A) A regulation prescribing an Act, or part of an Act, for the purposes of subsection 3(1), definition of environment protection legislation, paragraph (l) may only be made with the concurrence of the Minister ...

  7. Vor 9 Stunden · 1 Executive summary On 10 March 2022, UN Secretary-General, António Guterres, stated that 1: “(...) there is renewed pressure to consider whether global governance systems are fit for purpose,