Suchergebnisse
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Vor 4 Stunden · The stereochemistry of the amino acid moiety was unambiguously confirmed using X-ray crystallography after conversion to the p-bromobenzamide derivative 117. Although it might require more steps than the ideal glycine aldol-based approach, this route was robust and provided reproducibly sufficient material (> 100 mg in one batch) to accomplish the total synthesis.
Vor 4 Stunden · The structures 1–4 have been determined based on NMR spectroscopy, X-ray crystallography, and chemical conversion, and have a bromine-bearing tetrahydropyran (THP) ring attached to C7 of a dioxabicyclo[4.4.0]decane framework (ABC ring system), common to the thyrsiferol family, and various alkyl substituents at C14. In the THP C ring, a twist-boat form was observed due to undesirable steric ...
Vor 4 Stunden · A single crystal of 32 was obtained, and the absolute conformation was determined by X-ray crystallography. For the synthesis of 1, the conversion of the tosyl group of compound 30 to a methyl group was examined. However, removal of the tosyl group was troublesome, and decomposition of the substrate occurred when sodium naphthalenide was ...
Vor 4 Stunden · / via embl/ Stephen Cusack, world-renowned structural biologist and former Head of EMBL Grenoble, reflects on his early influences, his achievements, and the lessons he’s learned as he embarks on his next adventure Structural biologis
Vor 4 Stunden · 52. 53. Structural basis for understanding transport. 54. Integrative structural biology in the era of accurate AI-based structure prediction AlphaFold-multimer v2.3 RoseTTAfold OpenFold UniFold …. AlphaLink Combinatorial assembly of larger complexes: MolPC, FoldDock, AFM-RL Many, if not most, cryoEM structures are now built using AlphaFold ...
Vor einem Tag · AbstractDeposition of amyloid-β (Aβ) peptides in the brain is a hallmark of Alzheimer’s disease. Aβs are generated through sequential proteolysis of the amyloid precursor protein by the γ-secretase complexes (GSECs).
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