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21. März 2024 · Zerebrale Kavernome, kurz CCM, sind gutartige Gefäßfehlbildungen, die im Gehirn lokalisiert sind. Im Rückenmark gelegene Kavernome werden als spinale Kavernome bezeichnet. Epidemiologie. Kavernome machen einen Anteil von 5 bis 15 % aller intrakraniellen vaskulären Malformationen aus.
Cerebral and spinal cavernomas are vascular malformations in the brain/spinal cord responsible for about 20 to 40 per cent of all spontaneous non-hypertensive intracerebral hemorrhages. A...
Definition. Cavernous malformations (CMs) are low-flow, central nervous system vascular malformations that may occur in the brain, spinal cord, or, rarely, the dura. They are also referred to as cavernomas or cavernous angioma.
- Kelly D. Flemming, Giuseppe Lanzino
- 2020
- Terminology
- Epidemiology
- Clinical Presentation
- Pathology
- Radiographic Features
- Radiology Report
- Treatment and Prognosis
- Differential Diagnosis
- Practical Points
Many alternative terms have been used over the years including cavernous hemangioma, cerebral cavernous malformation or simply cavernoma.As these lesions are not neoplastic, it has been argued that the terms 'hemangioma' and 'cavernoma' should be avoided. Additionally, it is important to note that according to newer nomenclature (ISSVA classificati...
Most patients who present symptomatically do so at 40-60 years of age. Most patients have single lesions. Multiple lesions may be familial and screening of family members may be indicated (see familial multiple cavernous malformation syndrome). Additionally, cavernous malformations, along with capillary telangiectasias, are commonly seen following ...
The majority of lesions remain asymptomatic throughout life and are found incidentally. Presentation due to hemorrhage may cause a headache, seizure or focal neurological deficit. The risk of hemorrhage is 1% per patient-year for familial cases, somewhat less for sporadic lesions, and very rare (<0.1% per patient-year) for incidental lesions 14.
Histologically cavernous malformations are composed of a "mulberry-like" cluster of hyalinized dilated thin-walled capillaries, with surrounding hemosiderin 3. These vessels are thrombosed to varying degrees. Unlike CNS capillary telangiectasia,there is no normal brain between the interstices of these lesions. On occasion, they are intimately assoc...
Cerebral cavernous malformations tend to be supratentorial (~80% cases) but can be found anywhere including the brainstem. They are usually solitary, although up to one-third of patients with sporadic lesions have more than one 2. Brain MRI with SWI or GRE is recommended for the investigation and follow-up of cerebral cavernous malformations 14. Fo...
When reporting cerebral cavernous malformations, the following information is recommended for inclusion 14: 1. field strength and sequences 2. when single or few, signal characteristics, size (measured on spin-echo sequences), and location 3. when multiple, an estimate of number (e.g. 20-30, more than 50) is considered more helpful than "too many t...
Many cavernous malformations are asymptomatic and can be treated conservatively. Symptoms can relate to mass effect, epileptic activity or repeated hemorrhage. Symptomatic lesions should, when possible, be resected and complete resection is curative 9.
The differential, when cavernous malformations are numerous, is that of other causes of cerebral microhemorrhages, including 2: 1. cerebral amyloid angiopathy: usually numerous small foci 2. chronic hypertensive encephalopathy: more common in the basal ganglia 3. diffuse axonal injury (DAI) 4. cerebral vasculitis 5. radiation-induced vasculopathy 6...
when numerous cerebral cavernous malformations are found around the periphery of a developmental venous anomaly these are likely to be part of one sporadic mixed vascular malformation rather than r...
21. März 2024 · Cerebral cavernous malformations (CCMs) are lesions involving capillaries in the central nervous system, characterized by dilated vascular channels (caverns), a leaky endothelium, and a lack of mature vessel wall elements. 1 CCMs are common, approaching 1% of the population based on autopsy studies and analysis of consecutive imaging ...
Cavernous malformations (CMs) are benign vascular malformations that maybe seen anywhere in the central nervous system. They are dynamic lesions, growing or shrinking over time and only rarely remaining stable. Size varies from a few millimeters to a few centimeters.
27. März 2023 · Cerebral cavernous malformations, also known as cavernomas or cavernous hemangiomas, are clusters of abnormal and hyalinized capillaries without intervening brain tissue. Due to recurrent microhemorrhages and thrombosis, they are typically surrounded by hemosiderin deposits and gliosis.
