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13. Jan. 2022 · 1 Definition. 2 Erweiterung. 3 Bewertung. 4 Literatur. 5 Quellen. Definition. Die CRAB-Kriterien werden bei der Diagnostik einer monoklonalen Gammopathie erhoben, um den Schweregrad bzw. das Progressionsrisiko zu definieren und Organschädigungen zu erkennen. Das Akronym CRAB steht für: Erweiterung.
- Making The Diagnosis of Multiple Myeloma
- The New Definition of Active Multiple Myeloma Is
- Original Crab Criteria For The Diagnosis of Multiple Myeloma
- Recommended Exam, Tests, and Imaging Studies For The Diagnosis of Myeloma
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Unlike many cancers, the diagnosis of active myeloma that requires therapy is based upon a combination of factors. A bone marrow biopsy (or biopsy from a tissue site where myeloma may have spread) is an essential part of the diagnosis. If the percentage of plasma cells is high, e.g. > 60%, the diagnosis of active myeloma is highly likely and part o...
Clonal bone marrow plasma cells >10% or biopsy-proven bony or extramedullary plasmacytoma and any one or more of the following CRAB features and myeloma-defining events:
Evidence of end organ damage that can be attributed to the underlying plasma cell proliferative disorder, specifically:
1. History and Physical Examination See Palumbo, A. et. al Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group. 2. Routine Laboratory Testing 1. Tests to assess blood cells, including a Complete Blood Count 2. Tests to assess kidney function, including serum creatinine, creatinine clearance, ...
The IMWG criteria include the original CRAB features and three myeloma-defining events for diagnosing multiple myeloma. Learn the updated criteria, the evidence for each marker, and the impact on treatment and management.
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Die CRAB-Kriterien sind Bestandteil der Diagnostik des multiplen Myeloms. [1] Definiert sind sie wie folgt: Dabei steht CRAB als Akronym für: C: hyperCalcaemia, Hyperkalzämie mit einem Serumkalziumwert von > 2,75 mmol/l oder > 0,25 mmol/l oberhalb des oberen Normwertes. R: Renal failure, Niereninsuffizienz mit einem ...
CRAB-/SLiM-Kriterien. Als Grundlage der Therapieindikation werden die SLiM-CRAB-Kriterien der IMWG verwendet: Diese beinhalten eine Plasmazellinfiltration von mehr als 10% und einer der folgenden Punkte: erhöhter Serum Kalzium Spiegel (Calcium): >0,25 mmol/l oberhalb des oberen Normwertes oder >2,75 mmol/l.
Tabelle 7: Kriterien zur Einleitung einer Therapie [IMWG, 2014; SLiM-CRAB Kriterien] Kriterium. Definition. CRAB. Hyperkalzämie (C) Calcium >2,75 mmol/l (>10,5 mg/dl) oder >0,25 mmol/l oberhalb des oberen Normwertes. Niereninsuffizienz (R) Kreatinin ≥2,0 mg/dl (>173 µmol/l) oder GFR <40ml/min. Anämie (A)
19. Mai 2016 · In 2014, the IMWG revised the diagnostic criteria for MM. 10 The revised diagnostic criteria for MM allow the use of specific biomarkers to define the disease in addition to the established CRAB features. They also allow the use of modern imaging tools to diagnose MM bone disease and clarify several other diagnostic requirements.
This International Myeloma Working Group consensus updates the disease definition of multiple myeloma to include validated biomarkers in addition to existing requirements of attributable CRAB features (hypercalcaemia, renal failure, anaemia, and bone lesions).
