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In toxicology, point of departure (POD) is defined as the point on a toxicological dose-response curve established from experimental data or observational data generally corresponding to an estimated low effect level or no effect level. It marks the beginning of extrapolation to toxicological reference dose RfD or reference concentration RfC.
16. Jan. 2018 · Toxicology. A point of departure can have many meanings, including where a journey begins. In toxicology, it has a particular meaning related to the dose at which a biological response is first observed and is a basis for making extrapolations needed for assessing risks.
- Shana J. Sturla
- 2018
Point of Departure: NOAEL versus benchmark dose. Unsicherheit und probabilistische Verfahren. Take home. Grenz- und Richtwerte in verschiedenen Regelungsbereichen. REACH: Derived no effect level (DNEL) PPP: Acceptable Operator Exposure Levels (AOEL) Biozidprodukte-Verordnung: Acceptable Exposure Levels (AEL)
The National Research Council’s vision for toxicity testing in the 21st century anticipates that points of departure (PODs) for establishing human exposure guidelines in future risk assessments will increasingly be based on in vitro high-throughput screening (HTS) data.
- Salomon Sand, Frederick Parham, Christopher J. Portier, Raymond R. Tice, Daniel Krewski
- 2016
15. Aug. 2016 · The PoD is an adopted practice for toxicological risk assessment and critical for deriving the ADE. •. The PoD selection involves evaluating all the toxicological and pharmacological data and identifying the critical effect. •. This manuscript discusses the unique considerations for selecting a PoD for pharmaceuticals. Abstract.
- Joel P. Bercu, Eric J. Morinello, Claudia Sehner, Bryan K. Shipp, Patricia A. Weideman
- 2016
22. Jan. 2023 · In classical toxicology, point-of-departure (POD) derivation is employed alongside assessment factors for in vivo hazard characterisation to determine reference values, i.e., the maximum dose or concentration of a chemical within a defined exposure time frame without a significant risk to an individual (More et al. 2021). Calculating ...
Systemic toxicity was assessed using a battery of in vitro NAMs to identify points of departure (PoDs) for a variety of biol. effects such as receptor-mediated and immunomodulatory effects (Eurofins SafetyScreen44 and BioMap Diversity 8 Panel, resp.), and general bioactivity (ToxCast data, an in vitro cell stress panel and high-throughput ...
