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  1. MATE1 is a poly-specific transporter that mediates the efflux of organic cations, such as metformin, in the kidney and the liver. Learn about its function, localization, substrates, inhibitors, polymorphisms, and clinical relevance.

  2. Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE (multidrug and toxic compound extrusion) family of transporters that are found in bacteria, archaea and eukaryotes.

  3. www.mate1.com › nw › indexMate1.com

    Hier sollte eine Beschreibung angezeigt werden, diese Seite lässt dies jedoch nicht zu.

  4. MATE1 is highly expressed in the kidney, liver, skeletal muscle and also in adrenal glands, testes and heart. MATE1 exchanges organic cations against protons both in influx as well as in efflux modes. Methods: Here, we examined the interaction of 25 antineoplastic agents with human MATE1.

    • Julia Grottker, Albert Rosenberger, Gerhard Burckhardt, Yohannes Hagos
    • 2011
  5. www.deutsche-apotheker-zeitung.de › pharmazie › arzneimittelEvrysdi®: Risdiplam - DAZ.online

    1. Mai 2021 · In vitro zeigte sich Risdiplam als Inhibitor der Effluxtransporter MATE1 oder MATE2-K (Multidrug and Toxin Extrusion Protein 1 und 2-K). Bis zur Klärung der klinischen Relevanz dieses Befundes ...

  6. 27. Apr. 2018 · The OCT/MATE inhibitor trimethoprim abolished TMAO translocation in MDCK-OCT2-MATE1 cells (p < 0.05). The present data suggest that MATE1 contributes to renal elimination of TMAO. For...

  7. MATE 1 Substrates. Drugs that are eliminated by the MATE1 transporter, a multidrug and toxin extrusion transporter located in the apical membrane in the kidney and liver that is encoded by the SLC47A1 gene. A first generation cephalosporin used to treat certain susceptible bacterial infections.