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The Sleeping Beauty transposon system is a synthetic DNA transposon designed to introduce precisely defined DNA sequences into the chromosomes of vertebrate animals for the purposes of introducing new traits and to discover new genes and their functions.
16. Sept. 2020 · The Sleeping Beauty transposon system is a nonviral DNA transfer tool capable of efficiently mediating transposition-based, stable integration of DNA sequences of choice into eukaryotic genomes.
- Maximilian Amberger, Zoltán Ivics
- 2020
Sleeping Beauty (SB) is a synthetic transposon that was constructed based on sequences of transpositionally inactive elements isolated from fish genomes. SB is a Tc1/mariner superfamily transposon following a cut-and-paste transpositional reaction, during which the element-encoded transposase intera ….
- Zoltán Ivics, Zsuzsanna Izsvák
- 2015
Sleeping Beauty (SB) is the first synthetic DNA transposon that was shown to be active in a wide variety of species. Here, we review studies from the last two decades addressing both basic biology and applications of this transposon. We discuss how host-transposon interaction modulates transposition ….
- Suneel A Narayanavari, Shreevathsa S Chilkunda, Zoltán Ivics, Zsuzsanna Izsvák
- 2017
4. Okt. 2016 · Sleeping Beauty (SB) is the first synthetic DNA transposon that was shown to be active in a wide variety of species. Here, we review studies from the last two decades addressing both basic biology and applications of this transposon. We discuss how host–transposon interaction modulates transposition at different steps of the transposition reaction.
- Suneel A Narayanavari, Shreevathsa S Chilkunda, Zoltán Ivics, Zsuzsanna Izsvák
- 2017
4. Nov. 2019 · The Sleeping Beauty (SB) transposon system is an efficient non-viral gene transfer tool in mammalian cells, but its broad use has been hampered by uncontrolled transposase gene activity from...
30. Dez. 2023 · Dieser Kapitel beschreibt die Mechanismen und Anwendungen von Sleeping Beauty, einem mobilen genetischen Element, das für die Einführung von Genen in verschiedene Genome genutzt wird. Sleeping Beauty ist ein Transposon, das eine Cut-and-Paste-Transposition durchgeführt und als DNA- oder RNA-Transfervehikel dient.
