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Abstract. In the human fungal pathogen Candida albicans, ARO1 encodes an essential multi-enzyme that catalyses consecutive steps in the shikimate pathway for biosynthesis of chorismate, a precursor to folate and the aromatic amino acids.
ARO1 1. Systematic Name. YDR127W. SGD ID. SGD:S000002534. Feature Type. ORF , Verified. Description. Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids 2 3.
3. Juni 2021 · One of the first enzymes appearing in the fungal aromatic amino acid biosynthesis pathway is the pentafunctional AROM polypeptide encoded by ARO1 gene. This enzyme is particularly interesting because of its complex, multi-domain structure that allows catalyzing five consecutive steps of the shikimate pathway (Duncan et al. 1988 ).
- Aleksandra Kuplińska, Kamila Rząd
- 2021
1. Sept. 2018 · The Aro1 PEST (p6G) strain produced 5.56 ± 1.0 g/liter PCA with a yield of 46 mg/g sucrose, representing a 3-fold increase relative to the values for the Aro1 WT (p6G) strain (1.78 ± 0.19 g/liter PCA and 15 mg/g sucrose), demonstrating enhanced flux through the heterologous pathway in the Aro1 degradation background.
- Michael E. Pyne, Lauren Narcross, Mindy Melgar, Kaspar Kevvai, Shoham Mookerjee, Gustavo B. Leite, V...
- 10.1128/AEM.01095-18
- 2018
- 2018/09/09
5. Mai 2022 · Abstract. In the human fungal pathogen Candida albicans, ARO1 encodes an essential multi-enzyme that catalyses consecutive steps in the shikimate pathway for biosynthesis of chorismate, a precursor to folate and the aromatic amino acids.
5. Dez. 1988 · Abstract. The ARO1 gene of Saccharomyces cerevisiae encodes the arom multifunctional enzyme. Specific inhibitors of amino acid biosynthesis have been used to obtain evidence that expression of a cloned ARO1 gene is regulated in response to amino acid limitation.
