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Ruth Lynfield, MD, FAAP is an Associate Editor of the 2024 and 2021 editions of Red Book and has been a member of the the Committee on Infectious Diseases since 2015.
In newborn infants, herpes simplex virus (HSV) infection can manifest as: (1) disseminated disease involving multiple organs, most prominently liver and lungs, and in 60% to 75% of cases also involving the central nervous system (CNS); (2) localized CNS disease, with or without skin, eye, or mouth involvement (CNS disease); or (3) disease localized to the skin, eyes, and/or mouth (SEM disease ...
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