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  1. 25. Juni 2024 · (D) Replacement of peptide backbone to 5-membered aromatic rings when filling triplet regions, the EKO strategy gave the scaffold alignment to bovine pancreatic trypsin inhibitor (PDB: BPTI) with RMSD of 0.37 Å. Retro-synthesis analysis of 5-membered aromatic triazoles as replacement of the peptide backbone giving out 12 TT-Mers.

  2. 10. Juni 2024 · Peptide synthesis with non-canonical or artificial residues further expands their utility (e.g. by modifying residues in cationic AMPs to enhance proteolysis resistance) . Figure 1C provides an overview of the primary applications of peptides in industry, biotechnology and therapeutics.

  3. 11. Juni 2024 · Peptide synthesis and conjugation. Synthetic peptides were ordered from CPC scientific with > 95% purity. NNJA peptides in the formats of monomer or dendrimer were conjugated by click...

  4. 6. Juni 2024 · The linear peptide precursor 9a, containing a C-terminal acyl hydrazide, was synthesized via Fmoc solid-phase peptide synthesis (SPPS) and oxidized after mild acidic cleavage and deprotection to the acyl azide peptide S9.

  5. 6. Juni 2024 · Chemical synthesis of sialylated carbohydrate precursors with orthogonal protection, followed by chemical sulfation. Further diversification of the ganglioside glycans is then achieved by...

  6. 25. Juni 2024 · Fucoidan, a sulfated polysaccharide found in algae, plays a central role in marine carbon sequestration and exhibits a wide array of bioactivities. However, the molecular diversity and structural complexity of fucoidan hinder precise structure–function studies. To address this, we present an automated method for generating well-defined linear and branched α-fucan oligosaccharides. Our ...

  7. 22. Juni 2024 · Advancements in medicine and pharmacology have led to the development of systems that deliver biologically active molecules inside cells, increasing drug concentrations at target sites. This improves effectiveness and duration of action and reduces side effects on healthy tissues. Cell-penetrating peptides (CPPs) show promise in this area. While traditional medicinal chemistry methods have ...