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  1. 8. Mai 2024 · A key step in assessing the potential human and environmental health risks of industrial and agricultural chemicals is to determine the toxicity point of departure (POD), which is the highest dose level that causes no adverse effect. Transcriptomic POD (tPOD) values have been suggested to accurately estimate toxicity POD values.

  2. www.epa.gov › iris › iris-glossaryIRIS Glossary | US EPA

    23. Mai 2024 · Point of Departure: The dose-response point that marks the beginning of a low-dose extrapolation. This point can be the lower bound on dose for an estimated incidence or a change in response level from a dose-response model (BMD), or a NOAEL or LOAEL for an observed incidence, or change in level of response.

  3. Vor 7 Stunden · The regulation of medical products provides an instructive point of departure. The FDA has recognized the need to revise its traditional paradigm for medical device regulation to fit adaptive AI/ML technologies, which enable continuous improvements and modifications to devices based on information gathered during use. AI/ML technologies should hasten an even more significant regulatory ...

  4. 9. Mai 2024 · A key step in assessing the potential human and environmental health risks of industrial and agricultural chemicals is to determine the toxicity point of departure (POD), which is the highest dose level that causes no adverse effect. Transcriptomic POD (tPOD) values have been suggested to accurately estimate toxicity POD values. One ...

  5. 14. Mai 2024 · The point of departure was highly dependent on measured chemical concentration which were often lower than the nominal concentration. Differentially expressed genes between chemicals within modes of action were compared and often showed statistically significant overlap.

  6. 22. Mai 2024 · Actual Time of Departure is the exact time a vessel or any other form of transportation is dispatched from the point of origin. The reverse of ATD is Actual Time of Arrival (ATA).

  7. 22. Mai 2024 · Estimated Time of Departure is the projection of time that is expected for a transport system to depart its point of origin/location. Also, it is an indicated time to start a particular trip/journey. This term is the same as Expected Time of Departure. All articles. Discover new logistics terms with the DHL logistics dictionary.