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Vor 6 Tagen · There are several established risk factors for RCC such as smoking, obesity, hypertension and chemical exposures, which have been described previously. An estimated 6%-9% of renal cancers have germline mutations in genes associated with cancer predisposition.
1. Mai 2024 · It may seem obvious now that it causes cancer, but we didn’t know it until scientists found it’s fingerprints in cases of lung cancer. So, to give us the best chance of finding new culprits, we need a detective.
17. Mai 2024 · Kidney cancer develops from the cells composing the renal parenchyma, primarily those that line the renal tubules 1. There are various morphological types of kidney...
1. Mai 2024 · A further mutational signature of unknown cause was ubiquitous but exhibited higher mutation loads in countries with higher incidence rates of kidney cancer. Known signatures of tobacco smoking ...
Vor einem Tag · In a subset of patients with renal tumours, multiple primary lesions may occur. Predisposition to multiple primary renal tumours (MPRT) is a well-recognised feature of some inherited renal cancer ...
21. Mai 2024 · Many people with earlier-stage kidney cancer are cured with surgery. But the cancer will return in up to 50% of people, most often those whose cancer has certain high-risk characteristics. Those characteristics include the presence of cancer in the lymph nodes nearest to the tumor or having tumor cells with what are called sarcomatoid features.
2. Mai 2024 · Scientists from the International Agency for Research on Cancer (IARC) and partner institutions have identified mutational signatures in kidney tumours that indicate the existence of multiple, geographically variable, and as-yet-undiscovered mutagenic exposures, potentially affecting tens of millions of people.
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