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9. Mai 2024 · p53 was discovered 45 years ago as an SV40 large T antigen binding protein, coded by the most frequently mutated TP53 gene in human cancers. As a transcription factor, p53 is tightly regulated by a rich network of post-translational modifications to execute its diverse functions in tumor suppression. Although early studies ...
Vor 2 Tagen · In this study, we observed that ARID1A-deficient colorectal cancer (CRC) cells showed synthetic lethal effects with a p53 activator, RITA (reactivating p53 and inducing tumor apoptosis). RITA, an ...
16. Mai 2024 · Tumour protein P53 ( TP53) is the most frequently mutated gene in human cancer and is referred to as the “guardian of the genome” ( 1, 2 ). The p53 protein can be activated by DNA damage and functions as a transcription factor to induce a cell cycle arrest, allowing damage repair, or to induce apoptosis ( 3 ).
Vor einem Tag · Cordycepin may activate the P53–P21 pathway to inhibit abnormal proliferation and migration of PASMC and promote apoptosis, offering a potential approach for PAH treatment. Scientific Reports ...
Vor 20 Stunden · The p53 protein is the master regulator of cellular integrity, primarily due to its tumor-suppressing functions. Approximately half of all human cancers carry mutations in the TP53 gene, which not only abrogate the tumor-suppressive functions but also confer p53 mutant proteins with oncogenic potential. The latter is achieved through so-called gain-of-function (GOF) mutations that promote ...
17. Mai 2024 · A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of ketones. While KDs improve certain health conditions and are popular for weight loss, detrimental effects have also been reported. Here, we show mice on two different KDs and, at different ages, induce cellular senescence in multiple organs, including the ...
Vor 3 Tagen · Author summary Li-Fraumeni syndrome, rooted in inherited mutations of the TP53 tumor suppressor gene, presents a complex interplay with microRNA34a (miR-34a), a known p53 target and modifier gene. Notably, miR-34 triple-null mice, despite exhibiting typical p53 responses and no evident cancer development, unveil a crucial role for miR-34 genes in suppressing tumorigenesis, particularly in ...
