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21. Juni 2024 · Jack Szostak Lab Uncovers New Mechanisms of RNA Stability and Interaction, Paving the Way for Origins of Life Discoveries. The Jack Szostak Lab has published new research in the Journal of the American Chemical Society on how RNA strands interact in new and fascinating ways.
Vor 3 Tagen · Under the guidance of Chris Switzer, he designed, built, and characterized the first five-stranded DNA helix that self-assembles around a metal-nucleated iso-guanine motif. From 2000-2004, he was an HHMI Post-Doctoral Fellow in Prof. Jack Szostak’s laboratory at Harvard Medical School. While at Harvard, he studied the de novo evolution of ...
2. Juli 2024 · Ellington, Andrew D.; Szostak, Jack W. Nature (London, United Kingdom) ( 1990 ), 346 ( 6287 ), 818-22 CODEN: NATUAS ; ISSN: 0028-0836 . Subpopulations of RNA mols. that bind specifically to a variety of org. dyes have been isolated from a population of random sequence RNA mols.
12. Juni 2024 · Jack Szostak Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules.
Vor 6 Tagen · While the prebiotic synthesis of the building blocks of life is well supported experimentally, no chemical process is known to selectively yield common biological RNA sequences and structures. RNA oligomers carrying functional information are generally believed to emerge from a large pool of random sequences as a result of Darwinian evolution. Herein, we profiled the nonenzymatic partitioning ...
12. Juni 2024 · The concept was made more precise by Jack Szostak in a paper in Nature in 2003 , with a small correction by Hazen, Carothers, Griffin, and Szostak in Proceedings of the National Academy of Sciences, USA in 2007 . In all of those papers, the null distribution assigns equal probability to all possible sequences.
Vor 19 Stunden · Irene Chen and Jack W. Szostak suggest that elementary protocells can give rise to cellular behaviors including primitive forms of differential reproduction, competition, and energy storage. Competition for membrane molecules would favor stabilized membranes, suggesting a selective advantage for the evolution of cross-linked fatty ...
