Multi-species Mapt Protein, High Purity & Specific Bioactivity!
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High Purity. Tau/0N3R Protein, Expressed in E. coli. With N-His Tag. High Bioactivity. Carrier-Free. Fragment A2-L352.
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21. Mai 2024 · Bei Alzheimer verkleben so genannte Tau-Proteine im Gehirn und sorgen so mit für die Symptome der Erkrankung wie Vergesslichkeit und Orientierungsstörung. An der Hochschule Coburg erforscht eine Molekularbiologin mit ihrem Team, wie sich die Aggregation der Tau-Proteine verhindern lässt. Zwei Peptide zeichnen sich als geeignete Blocker ab.
21. Mai 2024 · In this study, we have developed an innovative ferritin nanocage-based system for the delivery of BODIPY-based tau fluorophores, aimed at detecting tau proteins in living human cells. This ...
Vor 6 Tagen · The accumulation of tau protein aggregates in the brain is one of the hallmarks of Alzheimer’s disease. Tau aggregates are thought to enter cells through the endolysosomal pathway and escape into the cytosol through a poorly understood mechanism.
2. Mai 2024 · The microtubule-associated Tau protein is found in the central nervous system (CNS) in six major isoforms. Neurodegenerative diseases have been linked to post-translational changes of Tau, most notably phosphorylation. Tau protein’s molecular diversity is highly helpful in the identification of neurodegenerative illnesses.
Vor 4 Tagen · We found that in primary astrocytes and neurons, endocytosis of tau seeds leads to their accumulation in lysosomes. This in turn leads to lysosomal swelling, deacidification, and recruitment of ESCRT proteins, but not Galectin- 3, to the lysosomal membrane. These observations are consistent with nanoscale damage of the lysosomal membrane.
13. Mai 2024 · G–I Quantification of the protein level of Tau (G), cleaved caspase 3 (H) or autophagy markers (I) in (F). All the protein levels were normalized with the β-Actin level. All the values were ...
Vor 6 Tagen · The prion-like spread of protein aggregates is a leading hypothesis for the propagation of neurofibrillary lesions in the brain, including the spread of tau inclusions associated with Alzheimer’s disease. The mechanisms of cellular uptake of tau seeds and subsequent nucleated polymerization of cytosolic tau are major questions in ...
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