Suchergebnisse
Suchergebnisse:
The lethality of the disease is caused by the bacterium's two principal virulence factors: (i) the polyglutamic acid capsule, which is anti- phagocytic, and (ii) the tripartite protein toxin, called anthrax toxin.
Cutaneous anthrax is rarely fatal if treated, because the infection area is limited to the skin, preventing the lethal factor, edema factor, and protective antigen from entering and destroying a vital organ. Without treatment, up to 20% of cutaneous skin infection cases progress to toxemia and death.
Milzbrandtoxin (auch: Anthrax-Toxin) ist ein Proteingemisch, das vom Milzbrand-Erreger, dem Bakterium Bacillus anthracis produziert wird und das verantwortlich für die Gefährlichkeit einer Milzbrandinfektion ist.
The exotoxins secreted by B. anthracis use CMG2 as the major toxin receptor and play essential roles in pathogenesis during the entire course of the disease. This review focuses on the activities of anthrax toxins and their roles in initial and late stages of anthrax infection.
- Shihui Liu, Mahtab Moayeri, Stephen H. Leppla
- 10.1016/j.tim.2014.02.012
- 2014
- 2014/06
Der Erreger von Anthrax bzw. Milzbrand, Bacillus anthracis, ist ein grampositives, aerobes, stäbchenförmiges Bakterium aus der Familie der Bacillaceae, das in der Lage ist, Endosporen auszubilden.
7. Sept. 2020 · Anthrax lethal toxin (LT) is a bipartite toxin comprising protective antigen, which binds cellular receptors, and the lethal factor (LF) protease. LT is the primary virulence factor of B....
28. Aug. 2013 · Bacillus anthracis, the causative agent of anthrax disease, is lethal owing to the actions of two exotoxins: anthrax lethal toxin (LT) and oedema toxin (ET). The key tissue targets...
