Suchergebnisse
Suchergebnisse:
18. Mai 1989 · Huo wu li ren: Directed by Lieh Wei. With Sheren Tang, Charine Chan, Regina Kent, Hau-ling Chan.
- Lieh Wei
- 1989-05-18
- Action, Drama
- Sheren Tang, Charine Chan, Regina Kent
- Abstract
- Patients and Methods
- Results
- Discussion
- Appendix
- Acknowledgments
- Abbreviations
The prevalence of diabetes is dramatically increasing throughout the world as well as in China with a 4.3% prevalence among 20- to 79-yr-old persons in 2007, estimated to increase to 5.6% in 2025 (1). Hyperglycemia and dyslipidemia are two major components of the metabolic dysregulation of type 2 diabetes and are crucial risk factors for cardiovasc...
Study design
The study was a randomized, double-blind, placebo-controlled and multiple-center trial consisting of a screening visit, a 2-wk run-in, and a 3-month treatment period. The study was approved by the Institutional Review Board of Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, and written informed consent was obtained from each patient. The study was conducted in accordance with the principles of the Declaration of Helsinki. The registration number is NCT00462046 (clinicaltria...
Patients
Eligibility criteria were: 1) age of 25–70 yr; 2) newly diagnosed type 2 diabetes according to the 1999 World Health Organization criteria: fasting plasma glucose 7 mmol/liter or greater and/or 2-h OGTT 11.1 mmol/liter or greater (14) and fasting plasma glucose less than 8 mmol/liter; 3) dyslipidemia with triglycerides greater than 150 mg/dl (1.70 mmol/liter), total cholesterol greater than 200 mg/dl (5.16 mmol/liter), and/or low-density lipoprotein (LDL)-cholesterol (c) greater than 100 mg/d...
Treatment
Patients were randomized to receive berberine (0.5 g, twice daily) or placebo prepared in indistinguishable tablets. A dose reduction to 0.25 g twice daily was suggested whenever the constipation occurred and lasted more than 2 wk. The berberine and placebo tablets were provided by Huashi Pharmaceutical Inc. (Shanghai, China). The berberine is extracted from rhizomes of Coptis chinensis Franch with acidic water (0.3% H2SO4) soaking and chromatographic purification and had a purity 97% or grea...
Baseline characteristics
Patients were middle-aged Chinese living in the Shanghai region. Of 116 randomized patients, 106 completed the study, four dropped out with one or two visits, and six were lost without any visits. The data of 110 participants including those four who dropped out were analyzed as shown in Table 1. The baseline variables are not significantly different between the berberine and placebo groups.
The primary outcomes
As compared with subjects who received placebo, those receiving berberine had a significant improvement in fasting plasma glucose and 2-h OGTT plasma glucose, HbA1c, triglyceride, total cholesterol, and LDL-c. Fasting plasma glucose decreased from 7.0 ± 0.8 to 5.6 ± 0.9 mm/liter with berberine and decreased from 6.8 ± 0.9 to 6.4 ± 1.6 mm/liter with placebo (Fig. 3B), with corresponding falls in 2-h glucose from 12.0 ± 2.7 to 8.9 ± 2.8 vs. 12.2 ± 2.4 to 11.0 ± 2.8 and in HbA1c from 7.5 ± 1.0 t...
The secondary outcomes
Body weight decreased from 68.7 ± 11.3 to 66.4 ± 11.8 kg with berberine, a significantly greater fall than that from 71.8 ± 11.2 to 70.5 ± 11.0 kg in the placebo group (Fig. 3A). A greater reduction of BMI was also found at 3 months in the berberine group than in the placebo group (P = 0.021) (Table 1). Systolic and diastolic blood pressure decreased from 124 ± 14 to 117 ± 15 and from 81 ± 9 to 77 ± 11 mm Hg in those treated with berberine, exceeding the fall from 126 ± 15 to 123 ± 14 and fro...
Berberine is usually used as an antibiotic drug for diarrhea in China. Berberine has also been used for diabetic patients in traditional Chinese medicine for hundreds of years. Recent studies have reported effects on hyperglycemia and dyslipidemia (4–13, 20). Based on these previous in vitro and in vivo studies, we performed a randomized, double-bl...
The investigators and coordinators of this study are as follows: Guang Ning, M.D., Ph.D., Xiao-ying Li, M.D., Ph.D., Jie Hong, Ph.D., Yi-fei Zhang, Ph.D., Na Zhu, M.D., Li Huo, M.D., Sheng-hong Gu, M.D., Jin-feng Tang, Hui-min Chen (Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School ...
We are indebted to all the patients who participated in this study. We are very grateful to Dr. Zachary T. Bloomgarden (Department of Endocrinology, Mount Sinai School of Medicine and Medical Center, New York, New York) for critical reading the manuscript. This work was supported by a grant from 973 Project (2006 CB 503904), Shanghai Committee for ...
ANCOVA,Analysis of covariance;BMI,body mass index;c,cholesterol;CRP,C-reactive protein;- Yifei Zhang, Xiaoying Li, Dajin Zou, Wei Liu, Jialin Yang, Na Zhu, Li Huo, Miao Wang, Jie Hong, Peih...
- 2008
Huo wu li ren (1989) cast and crew credits, including actors, actresses, directors, writers and more.
Huo wu li ren (HK Title) Country : Hong Kong: Film Company : Grandwell Film Production: Genre : Drama: Video : Colour: Audio : Speaking (Cantonese) HK Gross : 2.149 M. HK$ Cast : Charine Chan Ka Ling Regina Kent Wai Ling Ken Lo Hui Kwong Cheng Yuen Man S ...
- Hong Kong
- Drama
- Grandwell Film Production
- 火舞儷人 (HK Title)Huo wu li ren (HK Title)
Huo wu li ren. 1989. Action/Drama. Advertisement. Cast. Sheren Tang Charine Chan Regina Kent Hau-ling Chan Pui-Kei Chan Yuen-Man Cheng Shan Chin Charlie Cho Hiu-Hung Fong Biu Gam. Director. Lieh ...
Huo wu li ren, For mo lai yan, สวยเผ็ดเชือดสุด...สุด, 火舞丽人
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