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  1. 21. März 2024 · Die Glucosetransporter der Familie GLUT sind Proteine, die aus etwa 500 Aminosäuren aufgebaut sind. Sie besitzen 12 transmembranäre Segmente und bilden so einen Kanal in der Zellmembran. Subtypen. Es sind mehrere unterschiedliche GLUT-Typen bekannt. Einige Subtypen (z.B. GLUT2) sind konstitutiv in die Zellmembran eingelagert.

    • Daniel Kamp
  2. Because glucose is a vital source of energy for all life, these transporters are present in all phyla. The GLUT or SLC2A family are a protein family that is found in most mammalian cells. 14 GLUTS are encoded by the human genome. GLUT is a type of uniporter transporter protein.

  3. GLUTs 1–5 are the most thoroughly studied and all have well established roles as glucose and/or fructose transporters in various tissues and cell types. The GLUT proteins are comprised of ~500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 membrane-spanning domains.

    • Mike Mueckler, Bernard Thorens
    • 10.1016/j.mam.2012.07.001
    • 2013
    • Apr-Jun 2013
  4. Alle GLUTs sind Mitglieder der Zuckertransporter in der Major-Facilitator-Superfamilie von Membrantransport -Proteinen. Sie weisen zwölf Transmembrandomänen auf. Inhaltsverzeichnis. 1 Struktur. 2 Typen und Entwicklung. 2.1 Typ 1. 2.2 Typ 2. 2.3 Typ 3. 3 Funktion. 4 Medizinische Bedeutung. 5 Literatur. 6 Einzelnachweise. Struktur.

  5. Abstract. GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human and they are categorized into three classes based on sequence similarity.

  6. 26. Juni 2020 · The SLC2 genes code for a family of GLUT proteins that are part of the major facilitator superfamily (MFS) of membrane transporters. Crystal structures have recently revealed how the unique protein fold of these proteins enables the catalysis of transport. The proteins have 12 transmembrane spans built from a replicated trimer substructure.

  7. The GLUT family consists of at least 14 members ( Scheepers et al., 2004 ). Most GLUTs are expressed by various brain cell types; for example, astrocytes express GLUT-1/2, oligodendrocytes express GLUT-2, microglia express GLUT-5, and neurons express GLUT-1/2/3/4 ( Szablewski, 2017 ). GLUT-3 is considered the principal neuronal glucose transporter.