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- Highlights for trifluoperazine
- Important warnings
- What is trifluoperazine?
- Trifluoperazine side effects
- Trifluoperazine may interact with other medications
- Trifluoperazine warnings
- How to take trifluoperazine
- Take as directed
- Important considerations for taking trifluoperazine
- Are there any alternatives?
1.Trifluoperazine oral tablet is available as a generic drug. It doesn’t have a brand-name version.
2.Trifluoperazine comes only as a tablet you take by mouth.
FDA warning: Increased risk of death in seniors with dementia
•This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous. •Trifluoperazine can increase the risk of death in seniors with dementia-related psychosis. People with dementia-related psychosis should not use this medication. Was this helpful?
Other warnings
•Tardive dyskinesia warning: This drug may cause tardive dyskinesia. This is a serious condition that causes movements you can’t control in your face, tongue, or other body parts. This condition may not go away even if you stop taking this drug. Talk to your doctor right away if you have symptoms. Your doctor may stop your treatment with this medication. •Neuroleptic malignant syndrome (NMS) warning: In rare cases, this drug may cause NMS. This is a life-threatening reaction. Symptoms can include high fever, muscle stiffness, confusion, and unstable blood pressure. They can also include a fast heart rate, heavy sweating, and arrhythmia (abnormal heart rhythm). Call your doctor right away if you have any symptoms of NMS. Your doctor may stop your treatment with this drug. •Infections warning: This drug can lower your white blood cell count. This may lead to infections. Tell your doctor right away if you have symptoms of infection, which can include fever, body aches, and chills. Your doctor will check your white blood cell counts before and during your treatment with this drug. If the counts drop too low, your doctor will stop your treatment with this drug. •Dementia warning: Research has indicated that this medication, which is a drug called an anticholinergic, can raise your risk of dementia.
Why it’s used
Trifluoperazine is used to treat schizophrenia and anxiety.
How it works
Trifluoperazine belongs to a class of drugs called antipsychotics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. It isn’t known exactly how this drug works. It may help control the amount of a chemical called dopamine in your brain. Dopamine plays a role in both schizophrenia and anxiety. Controlling it may improve your condition.
More common side effects
The more common side effects of trifluoperazine can include: •drowsiness •dizziness •skin reactions, such as: •skin darkening •redness •itchiness •irritation •dryness •increased sweating •rash •dry mouth •sleeping trouble •loss of ovulation and menstrual period (tends to be temporary) •fatigue •muscle weakness •loss of appetite •lactation (producing breast milk) •blurry vision •restlessness or feeling like you have to move If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following: •Neuroleptic malignant syndrome. Symptoms can include: •fever •stiff muscles •confusion •sweating •changes in heart rate and pulse •unstable blood pressure •Tardive dyskinesia. Symptoms can include: •being unable to control your face, tongue, mouth, jaw, or other body parts •Low white blood cell count. This may lead to an infection. Symptoms of an infection can include: •fever •body aches •chills •Orthostatic hypotension. This is a sudden drop in blood pressure when you stand up from a sitting or lying position. Symptoms can include: •lightheadedness or fainting •Trouble controlling your body temperature (may cause you to feel too warm) •Seizures Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Trifluoperazine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Allergy warning
This drug can cause a severe allergic reaction. Symptoms can include: •trouble breathing •swelling of your throat or tongue •rash •hives •itching If you develop these symptoms, call 911 or go to the nearest emergency room. Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Alcohol interaction warning
Drinking alcohol can increase your risk of side effects from this drug. If you drink alcohol, talk to your doctor.
Warnings for people with certain health conditions
For people with a heart condition: Tell your doctor about your heart issue before starting this drug. They’ll tell you if this drug is safe for you. For people with seizures or epilepsy: This drug may cause you to have more seizures. Ask your doctor if this drug is safe for you. You should also talk to your doctor if you have a condition that could cause you to have seizures more easily, such as Alzheimer’s disease. For people with a low white blood cell count: Tell your doctor if you have a history of low white blood cell levels before starting treatment. This drug can further lower your white blood cell levels. For people with glaucoma: Ask your doctor if this drug is safe for you. This drug can dilate your pupils (widen the dark area in the middle of your eye). For people with liver problems: This drug is broken down in the liver. If you have liver damage, you may not be able to break down this drug very well. This can lead to increased side effects. If you have liver damage, ask your doctor if this drug is safe for you. For people with diabetes: This drug can increase your blood sugar levels. In rare cases, it can decrease blood sugar levels. You and your doctor should monitor your blood sugar levels more closely during treatment. If your blood sugar levels increase, your doctor may change your diabetes medications.
All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:
•your age
•the condition being treated
•how severe your condition is
•other medical conditions you have
•how you react to the first dose
Trifluoperazine oral tablet is used for long-term treatment of schizophrenia and short-term treatment of anxiety. It comes with serious risks if you don’t take it as prescribed.
If you stop taking the drug suddenly or don’t take it at all: If you stop taking this drug suddenly or change your dosage without talking to your doctor, you increase your risk of developing neuroleptic malignant syndrome (NMS). If you don’t take this drug at all, your symptoms of schizophrenia or anxiety likely won’t improve.
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:
•spasms of your neck muscles
•trouble swallowing
General
•You can take this drug with or without food. Taking it with food may help reduce upset stomach. •Take this drug at the time(s) recommended by your doctor. •You can cut or crush the tablet.
Storage
•Store trifluoperazine at room temperature between 68°F and 77°F (20°C and 25°C). •Keep this drug in the container it comes in. •Don’t store this medication in moist or damp areas, such as bathrooms.
Refills
A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.
There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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