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  1. de.wikipedia.org › wiki › Raf_(Protein)Raf (Protein) – Wikipedia

    Bei den Raf-Proteinen handelt es sich um eine Familie von Proteinkinasen, welche die Isoformen A-Raf, B-Raf und C-Raf umfasst und zu den Serin/Threonin-Proteinkinasen der heterogenen Klasse EC 2.7.11.1 gehört. Sie spielen eine wichtige Rolle im MAP-Kinase-Signalweg und Ras-Raf-Signalweg.

  2. flexikon.doccheck.com › de › RasRas/Raf/MAPK-Signalweg - DocCheck Flexikon

    24. Feb. 2023 · Der Ras/Raf/MAPK-Signalweg oder MAP-Kinase-Weg ist eine wichtige Signaltransduktionskaskade, die durch das aktivierte G-Protein Ras initiiert wird.

    • Utku Bayram

  3. Bilder

    • PDB-101: Molecule of the Month: RAF Protein Kinases
    • B-RAF mutations in human cancer.B-RAF is represented using the ...
    • 5 Ras/Raf/MAP kinase signalling pathway (Wong and Ng 2008 ...
    • SOS-RAS-RAF-MAP kinase pathway | Download Scientific Diagram
    • Transcription Factor Dp1

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  4. en.wikipedia.org › wiki › Raf_kinaseRAF kinase - Wikipedia

    RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction.

  5. www.ncbi.nlm.nih.gov › pmc › articlesRaf Kinases: Function, Regulation and Role in Human Cancer

    Function of Raf family kinases has been shown to play a role during organism development, cell cycle regulation, cell proliferation and differentiation, cell survival and apoptosis and many other cellular and physiological processes.

    • Deborah T. Leicht, Vitaly Balan, Alexander Kaplun, Vinita Singh-Gupta, Ludmila Kaplun, Melissa Dobso...
    • 10.1016/j.bbamcr.2007.05.001
    • 2007
    • 2007/08

  6. www.nature.com › articles › onc2011160Raf kinases in cancer–roles and therapeutic opportunities

    16. Mai 2011 · Raf are conserved, ubiquitous serine/protein kinases discovered as the cellular elements hijacked by transforming retroviruses. The three mammalian RAF proteins (A, B and CRAF) can be activated...

    • G Maurer, B Tarkowski, M Baccarini
    • 2011

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  8. www.nature.com › articles › nrm3979Regulation of RAF protein kinases in ERK signalling - Nature

    23. Apr. 2015 · The three cellular RAF family kinases (ARAF, BRAF and CRAF) were identified 30 years ago on the basis of their homology to the viral oncoprotein v-raf. They were then found to be core members...

  9. www.nature.com › articles › s41568/023/00650-xThe role of CRAF in cancer progression: from molecular ... -...

    9. Jan. 2024 · The RAF family of kinases includes key activators of the pro-tumourigenic mitogen-activated protein kinase pathway. Hyperactivation of RAF proteins, particularly BRAF and CRAF, drives...