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  1. Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE (multidrug and toxic compound extrusion) family of transporters that are found in bacteria, archaea and eukaryotes.

  2. MATE1 is a poly-specific transporter that mediates the efflux of organic cations, such as metformin, in the kidney and the liver. Learn about its function, localization, substrates, inhibitors, polymorphisms, and clinical relevance.

  3. 27. Apr. 2018 · The OCT/MATE inhibitor trimethoprim abolished TMAO translocation in MDCK-OCT2-MATE1 cells (p < 0.05). The present data suggest that MATE1 contributes to renal elimination of TMAO. For...

    • A Gessner, J König, M F Fromm
    • 2018
  4. MATE1 is highly expressed in the kidney, liver, skeletal muscle and also in adrenal glands, testes and heart. MATE1 exchanges organic cations against protons both in influx as well as in efflux modes. Methods: Here, we examined the interaction of 25 antineoplastic agents with human MATE1.

    • Julia Grottker, Albert Rosenberger, Gerhard Burckhardt, Yohannes Hagos
    • 2011
  5. 16. Sept. 2016 · Here we found that the multidrug and toxin extrusion protein 1 (MATE1) transports imatinib with a manifold higher affinity. MATE1 mainly mediates the cellular uptake of imatinib into targeted...

    • S Harrach, C Schmidt-Lauber, T Pap, H Pavenstädt, E Schlatter, E Schmidt, W E Berdel, U Schulze, B E...
    • 2016
  6. 1. Okt. 2006 · Human MATE1 (hMATE1) is predominantly expressed and localized to the luminal membr... Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations | American Journal of Physiology-Cell Physiology

  7. Der Grundschulkönig bietet eine umfangreiche Sammlung von Arbeitsblättern mit Matheaufgaben für die 1. Klasse an, die in der Nachhilfe, zu Hause, in der Schule oder der Mittagesbetreuung eingesetzt werden können. Diese können für Kinder in der 1. Klasse Grundschule in Mathematik zum Wiederholen, Vertiefen und Intensivieren des bereits ...

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