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PI | Thewackerlab. Matthias G. Wacker. "The physical and biological realms converge in clinical applications. Our discipline, pharmaceutical science, leverages a deeper understanding of molecular interactions. This is the essence of bioprediction: Creating safer medicines by learning of their complex mechanics."
Welcome to the Wacker Lab at the Icahn School of Medicine at Mount Sinai. We are a structural pharmacology lab mainly interested in the molecular basis of serotonin signaling and neurotransmitter transport. Our goal is not only to understand the mechanics of these processes using a variety of structural, biophysical, and pharmacological methods
We revolutionize drug delivery through cutting-edge research and data-driven insights. Our multidisciplinary team combines data science and drug delivery expertise to predict the performance of new formulations in patients accurately.
- Meaning
- Differences in Perceived Levels of Offensiveness
- In Popular Culture
- Further Reading
- External Links
The terms wank and wanker originated in British slang during the late 19th and early 20th century. In modern usage, it is usually a general term of contempt rather than a commentary on sexual habits. Wanker has similar meanings and overtones to American pejoratives like jerk or jerk-off. More generally, wanker can carry suggestions of egotistical a...
In December 2000, the Advertising Standards Authority published research on attitudes of the British public to pejoratives. It ranked wanker as the fourth most severe pejorative in English. The BBC describes it as "moderately offensive" and "almost certain" to generate complaints if used before the watershed. In Australia, it is considered mildly o...
"The Winker's Song (Misprint)" by Ivor Biggun is one of many songs about masturbation. It describes the singer: "I'm a wanker, I'm a wanker. And it does me good like it bloody well should", and it reached number 22 in the 1978 UK charts. It was banned by BBC Radio 1and every national radio and television service. Phil Collins used the word in his 1...
Jenny Cheshire, 1991, English Around the World: sociolinguistic perspectives, Cambridge University Press, ISBN 0-521-39565-8.Tony McEnery, 2005, Swearing in English: Bad Language, Purity and Power from 1586 to the Present, Routledge, ISBN 0-415-25837-5.Media related to Wankerat Wikimedia CommonsDaniel Wacker, PhD Assistant Professor Department of Pharmacological Sciences Department of Neuroscience Daniel.Wacker@mssm.edu . Omar Sanchez-Reyes, PhD
Our lab is mainly focused on developing a structural and molecular understanding of serotonin mediated signaling that controls mood, sleep, cognition, and consciousness. We combine x-ray crystallography, cryo-EM and pharmacological assays to better understand how serotonin, therapeutics such as antipsychotics, and illicit drugs such as LSD ...
Developing and. characterizing long-acting injectable formulations of therapeutic peptides. Read More.
