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6. Dez. 2022 · T cells in transplantation: ready and willing to reject. By. Gavin Mason. Credit: Peter Dazeley / Getty. Transplantation is one of the great breakthroughs of medical science, and in the...
- Gavin Mason
23. Okt. 2020 · T cells in health and disease. Article Open access 19 June 2023. Tolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for autoimmune...
- Enrico Velardi, Jennifer J. Tsai, Jennifer J. Tsai, Marcel R. M. van den Brink, Marcel R. M. van den...
- 2021
27. März 2020 · Recent Findings. Advances in transplantation deepen understanding of T reg differentiation, expansion, transcription, co-stimulation, and signaling. T cell receptor (TCR) sequencing and single-cell analytics allow unprecedented insight into T reg repertoire diversity and phenotypic heterogeneity.
- Ikbale El-Ayachi, William K. Washburn, Austin D. Schenk
- 2020
An Immune Atlas of T Cells in Transplant Rejection: Pathways and Therapeutic Opportunities. Short, Sarah MBBS 1; Lewik, Guido MD 1; Issa, Fadi DPhil, FRCS 1. Author Information. 1 Nuffield Department of Surgical Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom. Received 15 July 2022. Revision received 10 January 2023.
Transplantation is a life-saving therapy for end-stage organ disease, yet the alloreactive T cell response poses a significant barrier to long-term graft survival. Seminal studies and emerging findings have defined the roles that T cell costimulatory and coinhibitory receptors play in tipping the balance between transplant rejection and tolerance.
- Mandy L. Ford
- 2016
1. Nov. 2023 · An Immune Atlas of T Cells in Transplant Rejection: Pathways and Therapeutic Opportunities. Transplantation. 2023 Nov 1;107 (11):2341-2352. doi: 10.1097/TP.0000000000004572. Epub 2023 Oct 21. Authors. Sarah Short 1 , Guido Lewik , Fadi Issa. Affiliation.
The obvious priming and accumulation of alloreactive memory T cells can occur via direct exposure to foreign MHCs during previous transplantations, blood transfusions and pregnancies. 1 – 3 In addition, alloreactive memory cells are generated as a result of heterologous immunity occurring when the peptides of commensal bacteria or environmental ...