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19. Sept. 2002 · Binding is noted also when the probe comprises both the full and two half p53-binding sites (XPCL, lane 9), whereas a similar length probe containing another potential p53-binding site in intron 3 (XPCintron3) is not bound by p53 (lane 10). In lanes where band shifts were observed, larger complexes were noted also, potentially because of ...
10. Aug. 2020 · The transcription factor, p53, is critical for many important cellular functions involved in genome integrity, including cell cycle control, DNA damage response, and apoptosis. Disruption of p53 results in a wide range of disorders including cancer, metabolic diseases, and neurodegenerative diseases. Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by protein aggregates ...
16. Apr. 2021 · Our structural studies reveal that p53 dimer can bind BCL-xL in a well-defined and specific manner. These observations together with our biochemical and cellular data, provide insights into the transcription-independent activity of p53-mediated mitochondrial apoptosis and the mechanism of its inactivation by p53 mutations.
15. Juni 1998 · As will be shown below , the slower migrating band (Figure 4C, closed arrow) corresponded to tetrameric p53, and the faster migrating band (Figure 4C, open arrow) corresponded to dimeric p53. Our results ( Figure 2A ) suggest that the same species of full‐length p53 could bind either to the one‐half‐site in M34 or to one or both of the two half‐sites in CON, but not to alternating ...
p53-Tetramere sind Transkriptionsfaktoren: sie binden an bestimmte Stellen der DNA und stimulieren die Bildung weiterer Proteine (z.B. p21) -> p21 bindet an bestimmte Enzyme, die den Eintritt in die Zellteilung bewirken (z.B. CDK2), und inaktiviert sie.
Although wild-type p53 shows no obvious ability to bind p63 or p73, mutations in p53 can alter the protein's conformation. This allows p53 to bind its sibling proteins, resulting in an inhibition ...
25. Apr. 2002 · Although the DO-7-band intensity was comparable in both cases, again there was no specific band revealed by antibody directed against the phosphorylated forms of p53 in TNFα-treated cell extracts ...
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Human Tumor Protein P53. High Purity & Specific Bioactivity!
