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Predicted band size: 53 kDa. Western blot analysis showing p53 expression in wild-type and p53 shRNA knockout in rat PC-12 cells. Beta-actin served as the loading control. This analysis shows the antibodies specificity due to detection in the endogenous p53 protein in wild-type but not in shRNA knockdown cell lysate.
1. März 2019 · In contrast to the above-mentioned cofactors, p63 and p73 have the same DNA recognition sequence as p53; they can bind at the majority of p53 binding sites and are thought to cooperate with p53 in ...
29. März 2024 · In non-small cell lung cancer (NSCLC), inactivating p53 mutations can drive resistance to cisplatin. Here, the authors develop fluplatin nanoparticles comprising a prodrug of cisplatin and ...
11. Juli 1995 · 1TSR, 1TUP. PubMed Abstract: Mutations in the p53 tumor suppressor are the most frequently observed genetic alterations in human cancer. The majority of the mutations occur in the core domain which contains the sequence-specific DNA binding activity of the p53 protein (residues 102-292), and they result in loss of DNA binding.
A specific band was detected for Phospho-p53 (S46) at approximately 65 kDa (as indicated) using 10 µg/mL of Rabbit Anti-Human Phospho-p53 (S46) Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1489). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system. Reconstitution Calculator.
Putting p53 in Context. TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative transcriptional program that touches upon a bewildering array of biological responses. Despite the many unveiled facets of the p53 network, a ...
9. März 2023 · The p53 protein is a sequence-specific DNA-binding transcription factor that, in response to stressful stimuli, regulates gene expression related to multiple cellular functions including, but not limited to, cell cycle arrest, cell apoptosis, cell growth, DNA repair, cell metabolism, and the immune response [ 1 ].
