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  1. Vor 5 Tagen · In this phase 1 trial, treatment of patients with ER+HER2− metastatic breast cancer with a selective catalytic inhibitor of the lysine acetyltransferase KAT6 shows a manageable safety profile ...

  2. Vor 5 Tagen · Eine Kombination von CDK4/6-Hemmung und antihormoneller Therapie kann sich unter Umständen lohnen. Patientinnen mit fortgeschrittenem hormonempfindlichem, HER2-negativem Brustkrebs, der sich aggressiv zeigt, können unter Umständen von einer Erstbehandlung mit einer Kombination aus CDK4/6-Hemmer und antihormoneller Therapie profitieren.

  3. Vor 3 Tagen · Breast cancer (BC) is the most common cancer that affects women, accounting for almost one-third of all cancer cases [].In 2020, globally, 2.3 million women were diagnosed with BC, 685,000 deaths were reported, and 7.8 million women who had been diagnosed with breast cancer in the past five years were still alive, making it the world's most prevalent cancer [].

  4. Vor 3 Tagen · Here, we report that DUX4 expression is a common feature of metastatic tumors, with ~10–50% of advanced bladder, breast, kidney, prostate, and skin cancers expressing DUX4. DUX4 expression is significantly associated with immune cell exclusion and decreased objective response to PD-L1 blockade in a large cohort of urothelial carcinoma patients.

  5. Vor 2 Tagen · Blockade of T cell co-inhibitory receptors, such as CTLA-4 and the PD-1/PD-L1 axis, has achieved major success in the treatment of diverse metastatic cancers compared to first-line chemotherapy (Doki et al., 2022; Hellmann et al., 2019; Klein et al., 2020; Larkin et al., 2019; Motzer et al., 2020; Stein et al., 2022). However, a majority of advanced cancer patients fail to respond to ICI due ...

  6. Vor 5 Tagen · Una nueva combinación de fármacos, libre de quimioterapia, reduce un 48 % el riesgo de progresión del cáncer de mama avanzado tipo HER2+/ER+, según un estudio.

  7. Vor 5 Tagen · 2 min. Una nueva combinación de fármacos, libre de quimioterapia, reduce un 48% el riesgo de progresión del cáncer de mama avanzado de tipo HER2+/ER+, según los resultados del ensayo PATRICIA ...