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Vor einem Tag · Die Otto-Warburg-Medaille gilt als die höchste Auszeichnung für Biochemiker und Molekularbiologen in Deutschland. Sieben der Preisträger haben auch den Nobelpreis erhalten. Seit 2007 ist die Medaille mit einem Preisgeld von 25.000 Euro dotiert, das ausschließlich von Elsevier und dessen Flaggschiff-Titel Biochimica et Biophysica Acta (BBA) gesponsert wird.
Vor 22 Stunden · In the 1920s, Otto Warburg's observations revealed that tumor cells exhibit enhanced glucose uptake and prefer glycolysis even in the absence of hypoxia, resulting in increased lactic acid production through aerobic glycolysis, known as the Warburg effect [1, 2]. Lactic acid has garnered scientific attention due to its association with tumor metabolism. Based on the results from Warburg ...
Vor 22 Stunden · Altered energy metabolism is a characteristic feature of cancer which had first been recognized by Otto Warburg (Warburg 1925; Warburg et al. 1924, 1927; reviewed in Liberti and Locasale 2016; Potter et al. 2016) in pioneering studies that built the foundation for subsequent in-depth experimentation on cell, genetic, proteomic, and molecular ...
Vor 2 Tagen · Cancer cell tends to reprogram energy metabolism from oxidative phosphorylation (OXPHOS) to aerobic glycolysis even under sufficient oxygen conditions, a phenomenon termed Warburg effect which was first described by Otto Warburg nearly a century ago . Although the Warburg effect has been extensively investigated, the detailed mechanisms triggering this effect during tumorigenesis is still ...
Vor 22 Stunden · Johannes Buchner (Otto-Warburg-Medaille 2024) und Marina Rodnina (Otto-Warburg-Medaille 2019) im Gespräch mit Werner Müller-Esterl
- 34 Min.
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- Tino Apel
Vor 5 Tagen · In the ~ 100 years since the discovery by Otto Warburg of the upregulation of glycolysis in cancer cells , there have been multiple hypotheses that “explain” the basis of this phenomenon. Most recent hypotheses posit genome, transcriptome, and proteomic-level alterations in cancer cells that underlie the uncontrolled cell proliferation, which is the hallmark of neoplasia [ 48 ].
Vor einem Tag · Based on Otto Warburg’s central theory – coined the ‘Warburg effect’ – cancer is a mitochondrial metabolic disease whereby mitochondrial damage causes fermentation to gradually replace respiration for cellular energy (5). It is a deregulated form of energetics whereby cancer cells “switch” to a very inefficient method of cellular energy generation, the glycolysis pathway, for ...
