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Vor einem Tag · Mutationally activated KRAS causes persistent activation of the RAF-MEK-ERK mitogen-activated protein kinase (MAPK) cascade. Whereas RAF and MEK kinases phosphorylate a highly restricted set of substrates, the closely related ERK1 and ERK2 serine/ threonine kinases directly or indirectly phosphorylate a diversity of functionally distinct proteins.
Vor 2 Tagen · The rapidly accelerated fibrosarcoma (RAF) kinase is a member of the mitogen-activated protein kinase kinase kinases (MAPKKKs) family. A-RAF, B-RAF, and RAF1 (or C-RAF) are three known subtypes of RAF in mammalian cells. While A-RAF and B-RAF show tissue-specific expression patterns, RAF1 is widely expressed, particularly in neurons of various brain regions, such as the hippocampus
Vor 4 Tagen · The canonical downstream signaling routes of FGF/FGFR encompass the Ras/Raf-MEK-MAPK (mitogen-activated protein kinase) pathway, phosphatidylinositol-3 kinase/protein kinase B (PI3K/AKT) pathway, PLCγ pathway, as well as signaling intermediates and transcription activators (STATs) [7, 21]. A unique docking protein, FRS2, exists in the FGFR signaling pathway. FRS2 specifically binds to members ...
Vor einem Tag · Oncogenic KRAS variants signal through various well-described carcinogenic signaling pathways, including RAF-mitogen-activated protein kinase (RAF-MAPK), phosphoinsositide-3-kinase (PI3K), and Ral GDS pathways. An overview of KRAS downstream effector pathways is provided .
Vor 2 Tagen · PD-L1 expression in NSCLC is influenced by various factors, including tumor hypoxia, a pro-inflammatory, interferon-gamma-rich microenvironment, as well as the activation of numerous intracellular pathways that promote cell motility and survival, including phosphatydil-inositol-3-kinase/AKT and Ras-Raf-Erk pathways . The mechanism of PD-L1 upregulation in metastatic lymph nodes may differ from ...
Vor 2 Tagen · Varying expression levels of known pathogenic genes among clusters were demonstrated in Fig. 4H. B-Raf proto-oncogene, serine/threonine kinase (BRAF), Tumor Necrosis Factor (TNF), Synaptic Ras GTPase Activating Protein 1 (SYNGAP1), Delta-Like Canonical Notch Ligand 4 (DLL4) and AT-Rich Interaction Domain 1B (ARID1B) were highly expressed in Cluster 1; while Phosphoinositide-3-Kinase Regulatory ...
Vor 4 Tagen · Formation of the tri-complex with either wild-type KRAS, NRAS, or HRAS proteins potently disrupted RAF-RBD binding in a concentration-dependent manner, with EC 50 values of 85, 66, and 82 nmol/L, respectively . Activity for oncogenic RAS mutant proteins was similar, ranging from 28 to 220 nmol/L. To explore the correlation between cellular and biochemical potencies of RMC-6236 for different ...
