The Only Specificity-Validated Ab. Tested for IHC, WB, IF/ICC & Flow. Try Now! Tested for IHC, WB, IF/ICC & Flow.
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TrueMAB primary antibodies.
Anti-tag antibodies.
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P53 Tumor Suppressor Protein. High Purity, High Activity, Low Endotoxin, Inquiry For Detail.
For use in ELISA, WB, IHC. Conjugated to Unconjugated
Suchergebnisse
Suchergebnisse:
18. Nov. 2022 · TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel...
24. Dez. 2021 · This review article discusses the role of p53 protein, a tumor suppressor, in regulating cell cycle, DNA repair, apoptosis, and metabolism. It also explores the molecular mechanisms and therapeutic strategies of mutant p53 proteins, which are involved in various human cancers.
1. März 2023 · The role of mutant p53 in cancer. Mutant p53 can result in loss-of-function of wild-type p53, dominant-negative repression of wild-type p53 by mutant p53, and gain-of-function with...
9. Mai 2024 · p53 was discovered 45 years ago as an SV40 large T antigen binding protein, coded by the most frequently mutated TP53 gene in human cancers. As a transcription factor, p53 is tightly regulated by a rich network of post-translational modifications to execute its diverse functions in tumor suppression.
23. Feb. 2022 · TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [ 1 ]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles in development, aging and cell differentiation [ 2 ].
- Liz J. Hernández Borrero, Wafik S. El-Deiry
- 2021/08
- 10.1016/j.bbcan.2021.188556
10. Okt. 2022 · The p53 tumour suppressor protein acts as a major barrier against cancer initiation and progression.
1. Aug. 2021 · Cancer. Therapeutics. 1. Tumor suppressor TP53: “Guardian of the Genome” TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [ 1 ]. Its main biological function appears to involve the protection of the DNA integrity of the cell.
