Suchergebnisse
Suchergebnisse:
6. Apr. 2017 · In toxicology, point of departure (POD) is defined as the point on a toxicological dose-response curve established from experimental data or observational data generally corresponding to an estimated low effect level or no effect level.
16. Jan. 2018 · A point of departure can have many meanings, including where a journey begins. In toxicology, it has a particular meaning related to the dose at which a biological response is first observed and is a basis for making extrapolations needed for assessing risks.
- Shana J. Sturla
- 2018
25. Okt. 2022 · The dose used for this purpose, however derived, is referred to in this opinion as the Reference Point (RP). This term, adopted by the EFSA in 2005 (EFSA, 2005a) is preferred to the equivalent term Point of Departure (PoD), used by others such as US EPA.
15. Aug. 2016 · The PoD is an adopted practice for toxicological risk assessment and critical for deriving the ADE. •. The PoD selection involves evaluating all the toxicological and pharmacological data and identifying the critical effect. •. This manuscript discusses the unique considerations for selecting a PoD for pharmaceuticals. Abstract.
22. Jan. 2023 · In classical toxicology, point-of-departure (POD) derivation is employed alongside assessment factors for in vivo hazard characterisation to determine reference values, i.e., the maximum dose or concentration of a chemical within a defined exposure time frame without a significant risk to an individual (More et al. 2021). Calculating ...
- 10.1007/s00204-022-03439-3
- 2023
- Arch Toxicol. 2023; 97(3): 721-735.
6. Juli 2016 · In this article, we compared two points of departure—the traditional BMDL and the recently proposed SNCD—applied to > 8,000 high-throughput experimental concentration–response curves generated during Tox21 Phase I (Tice et al. 2013).
To understand the mechanism of toxicity, a combination of aryl hydrocarbon receptor (Ahr)-deficient (Ahr-/-) mice, primary hepatocytes, luciferase reporter gene assays, in silico ligand docking and ultra-performance chromatog.-quadrupole time-of-flight mass spectrometry-based metabolomics was used.
