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p53, also known as Tumor protein P53, cellular tumor antigen p53 ( UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. [5] .
- G1-Block
- G2-Block
- Apoptose
Zum einen kann die Unterbrechung der Zellteilung in der G1-Phase, also vor dem Restriktionspunkt erfolgen. p53 induziert hierbei die Expression des Proteins p21, welches den D-Cyclin/CDK4/6-Komplex, einen wachstumsfaktorabhängigen und den Cyclin E/CDK2-Komplex, einen wachstumsfaktorunabhängigen Trigger des Übergangs aus dem G1-Stadium in die S-Phas...
Ein Arrest der Zellteilung kann ebenfalls nach fehlerhafter oder unvollständiger Replikation des Genoms (in der S-Phase) während des G2-Stadiums erfolgen. Hier verhindert p53 die Bildung des B-Cyclin/CDK1-Komplexes, welches essentiell für den Eintritt der Zelle in die Mitosephaseist.
Bei extremen Schäden wird die Apoptose durch Induktion des BAX-Proteins aus der Bcl-2-Familie eingeleitet. Dieses ist in der Lage, über die Aktivierung von Caspasen eine entsprechende Signalkaskade auszulösen. Dabei wird p53 in der Regel durch die Checkpointkinase 1/2 (Chk1/Chk2) phosphoryliert, was zur Stabilisierung von p53 führt. Eine Inhibition...
25. Okt. 2023 · The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and growth of tumors.
14. Dez. 2018 · Mutation-type p53 immunostaining serves as an indicator of the Cancer Genome Atlas (TCGA)-based molecular subtype of endometrioid carcinoma with the worst prognosis, especially when applied as part of a diagnostic algorithm 1,2.
- Martin Köbel, Brigitte M. Ronnett, Naveena Singh, Robert A. Soslow, C. Blake Gilks, W. Glenn McClugg...
- 10.1097/PGP.0000000000000488
- 2019
- 2019/01
USA.gov. The p53 gene like the Rb gene, is a tumor suppressor gene, i.e., its activity stops the formation of tumors. If a person inherits only one functional copy of the p53 gene from their parents, they are predisposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood.
- 1998
24. Dez. 2021 · The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene is mutated in approximately half of all human malignancies, including those of the breast, colon, lung, liver, prostate, bladder, and skin.
The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.
