Suchergebnisse
Suchergebnisse:
die Hsp100/Clp-Familie, die Hsp90-Familie, die Hsp70-Familie, die Hsp60/GroEL-Familie und; die kleinen Hitzeschockproteine (sHsps). Man kann die Chaperone nicht auf ein gemeinsames Urprotein zurückführen. Sie stellen eine heterogene Klasse dar, deren Mitglieder zu verschiedenen Zeitpunkten der Evolution entstanden.
Hsp100 (Clp family in E. coli) proteins have been studied in vivo and in vitro for their ability to target and unfold tagged and misfolded proteins. Proteins in the Hsp100/Clp family form large hexameric structures with unfoldase activity in the presence of ATP.
Overwhelming evidence suggests that ClpB/Hsp100 proteins play decisive roles in cell adaptation to HS. Mutant bacteria and yeast cells lacking active ClpB/Hsp100 proteins are critically sensitive to high-temperature stress. Likewise, Arabidopsis, maize and rice mutants lacking cytoplasmic ClpB proteins are very sensitive to heat. In this study ...
- Ratnesh Chandra Mishra, Anil Grover
- 2016
Abstract. The HSP100/Clp proteins are a newly discovered family with a great diversity of functions, such as increased tolerance to high temperatures, promotion of proteolysis of specific cellular substrates and regulation of transcription.
- Eric C. Schirmer, John R. Glover, Mike A. Singer, Susan Lindquist
- 1996
29. Jan. 2020 · Nature - A combination of optical tweezers and fluorescent-particle tracking is used to dissect the dynamics of the Hsp100 disaggregase ClpB, and show that the processive extrusion of polypeptide...
- Mario J. Avellaneda, Kamila B. Franke, Vanda Sunderlikova, Bernd Bukau, Axel Mogk, Sander J. Tans
- 2020
Die „Reparatur“ wird durch ein kooperierendes Team von zwei Chaperonen – der französische Ausdruck für „Anstandsdame“ – mit den Bezeichnungen Hsp70 und Hsp100 bewerkstelligt. Die Heidelberger Wissenschaftler konnten nun zeigen, dass die Aktivität des Hsp100-Chaperons durch einen eingebauten molekularen Schalter reguliert wird.
1. Sept. 2002 · Hsp100 is proven to be critical for the acquisition of thermotolerance as shown by transgenic and mutation based analyses. There are indications that plant Hsp100 proteins interact and recruit components of translational machinery to specific mRNAs in order to enhance their translation.
