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  1. broadpharm.com/PROTAClinkers

    AnzeigeBTK Kinase inhibitor - VHL Ligand 1, P131, dBET1, MZ1

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    VHL Ligand, AHPC, PEG amine, acid, azide, alkane linker & more PROTAC Linkers available! Insertion of PEG increases the water-solubility of the molecules

    5,000 + PEG in stock · Commitment to Excellence

    Types: PEGylation reagent, PEG linker, DBCO reagent, Azide PEG, PEG maleimide, Amino PEG

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      ADC Linkers, dye labeling tools

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    • PEGylated Lipids

      Various PEGylated Lipids Available

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  1. flexikon.doccheck.com › de › RasRas/Raf/MAPK-Signalweg - DocCheck Flexikon

    24. Feb. 2023 · Der Ras/Raf/MAPK-Signalweg oder MAP-Kinase-Weg ist eine wichtige Signaltransduktionskaskade, die durch das aktivierte G-Protein Ras initiiert wird.

    • Utku Bayram

  2. de.wikipedia.org › wiki › Raf_(Protein)Raf (Protein) – Wikipedia

    Bei den Raf-Proteinen handelt es sich um eine Familie von Proteinkinasen, welche die Isoformen A-Raf, B-Raf und C-Raf umfasst und zu den Serin/Threonin-Proteinkinasen der heterogenen Klasse EC 2.7.11.1 gehört. Sie spielen eine wichtige Rolle im MAP-Kinase-Signalweg und Ras-Raf-Signalweg.

  3. Bilder

    • PDB-101: Molecule of the Month: RAF Protein Kinases
    • B-RAF mutations in human cancer.B-RAF is represented using the ...
    • 5 Ras/Raf/MAP kinase signalling pathway (Wong and Ng 2008 ...
    • Transcription Factor Dp1
    • Voie de signalisation des MAP-kinases, avec les voies RAS-RAF-MEK-ERK ...

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  4. en.wikipedia.org › wiki › Raf_kinaseRAF kinase - Wikipedia

    RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for Rapidly Accelerated Fibrosarcoma.

  5. www.ncbi.nlm.nih.gov › pmc › articlesRaf Kinases: Function, Regulation and Role in Human Cancer

    Function of Raf family kinases has been shown to play a role during organism development, cell cycle regulation, cell proliferation and differentiation, cell survival and apoptosis and many other cellular and physiological processes.

    • Deborah T. Leicht, Vitaly Balan, Alexander Kaplun, Vinita Singh-Gupta, Ludmila Kaplun, Melissa Dobso...
    • 10.1016/j.bbamcr.2007.05.001
    • 2007
    • 2007/08

  6. www.spektrum.de › lexikon › biologieRaf-Kinasen - Lexikon der Biologie - Spektrum.de

    Raf-Kin a sen, Bezeichnung für cytosolische Serin-Threonin-Kinasen ( Proteinkinasen) mit zentraler Funktion in der Transduktion von Wachstumsfaktor-vermittelten Signalen von der Plasma- Membran in den Zellkern. 3 Gene codieren für 3 verschiedene Raf-Kinasen: c-Raf-1, A-Raf und B-Raf, deren relative Molekülmassen zwischen 70.000 und 75.000 liegen...

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  8. www.nature.com › articles › onc2011160Raf kinases in cancer–roles and therapeutic opportunities

    16. Mai 2011 · Raf are conserved, ubiquitous serine/protein kinases discovered as the cellular elements hijacked by transforming retroviruses. The three mammalian RAF proteins (A, B and CRAF) can be activated...

  9. www.nature.com › articles › s41392/023/01705-zTargeting the RAS/RAF/MAPK pathway for cancer therapy: from ... -...

    18. Dez. 2023 · RAF kinase is a primary mediator of the MAPK pathway, responsible for the sequential activation of downstream targets, such as MEK and the transcription factor ERK, which control numerous...