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  1. FunPat works with dynamic expression data comparing two experimental conditions (e.g. treatment vs. control) or a single condition vs. a baseline (e.g. time 0). FunPat offers the following types of analyses: – differential expression analysis of dynamic expression data; – model-based clustering of temporal expression profiles, without ...

  2. microarray technique, RNA-seq avoids the design of specific probes, enabling a higher number of transcripts to be measured on a wider dynamic range.

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  4. 1. Juni 2015 · FunPat pipeline. FunPat takes as input the expression data and the functional annotations organized according to Gene Sets, which can be defined as GO terms, pathways or other sets depending on the annotation database used as input. A summary of FunPat analysis pipeline is displayed in Figure 1.

  5. Methods: Here we present FunPat, an R package for time series RNA sequencing data that integrates gene selection, clustering and functional annotation into a single framework. FunPat exploits functional annotations by performing for each functional term, e.g. a Gene Ontology term, an integrated selection-clustering analysis to select ...

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