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Fipronil is an insecticide of the phenylpyrazoles class and an active ingredient of one of the popular ectoparasiticide veterinary products, Frontline. Frontline is commonly used on dogs and cats to kill fleas, and all stages of ticks (brown dog ticks, American dog ticks, lone star ticks) which may carry Lyme disease, and mites.
1. Aug. 2021 · Fipronil is a contact or stomach poison that inhibits the gamma-aminobutyric acid (GABA)-gated chloride channel leading to hyperexcitation, convulsions, paralysis, and death of insects (Gant et al., 1998).Compare to older-generations pesticides with a similar mode of action such as lindane (γ-HCH), dieldrin, and endosulfan, fipronil showed higher selective toxicity owing to its higher binding ...
Fipronil. Fipronil is a phenylpyrazole antiparasitic agent introduced in the United States in 1996 as a flea and tick control product. It is marketed for veterinary use as Frontline Top Spot and Frontline Spray (Merial; Duluth, Georgia). It may be found in combination with methoprene, an insect growth regulator (Frontline Plus, Merial).
23. Sept. 2024 · Fipronil residues and its primary metabolites have been found in a variety of environmental samples including soils, plants, water and animal products. The insecticidal metabolites of fipronil were discovered to be present in varied concentrations in water runoff from agricultural, unban, and mixed land used in many US states.
1. Jan. 2023 · Fipronil (3 mg/kg b.w./day) to rats; fipronil (3 and 10 mg/kg b.w./day) to mice Exposure time- 14 days: Fipronil exposure reduced mRNA expressions of Gstm1, Gsta2, Gsta4, Gstp1, Gstm2, Gstt2, and Gsta5, in liver, but enhanced expression of Gsta2 in the CAR mouse liver. Expression of detoxification enzymes such as Cyp2b2, Cyp2b1, and Cyp3a1 was ...
1. Apr. 2023 · Boxplots of the concentration of fipronil (FP), fipronil sulfide (FP-SFI), fipronil desulfinyl (FP-DES), fipronil amide (FP-AM), fipronil sulfone (FP-SFO), fipronil detrifluoromethylsulfinyl (FP-DTF), and sum of FP, FP-SFI, FP-DES, FP-AM, FP-SFO, and FP-DTF (ΣFPs) between urban and rural areas. The band inside the box shows the median (50th). Bottom and top of the box are the first (25th) and ...
10. Sept. 2021 · Fipronil (FP) is widely used as a highly effective insecticide worldwide, thereby raising concern about environmental contamination and risk for human health. However, data on the occurrence of FP and its transformation products (FPs) in human blood and urine are limited. In this study, 39 pairs of serum, plasma, blood cells (BCs), and urine ...
1. Feb. 2022 · (a) Effect of the scan rate on fipronil peak current at 50 μM on the TiO 2-PTI/SPE in Britton-Robinson buffer (pH = 10). (b) Effect of the scan rate on fipronil sulfone peak current at 50 μM on the TiO 2-PTI/SPE in Britton-Robinson buffer (pH = 10). (SWV measurements were performed with a step potential of 0.004 V, and an amplitude of 0.02 V).
1. März 2020 · Fipronil's mechanism of action is to block insect's chloride channels that are controlled by gamma-aminobutyric acid (GABA) in the neurons of the central nervous system. To assess the direct or indirect potential risks of fipronil, a variety of studies have been performed on different animals including Daphnia pulex, fish, rat, honey bees and dogs [ [4] , [5] , [6] ].
1. Apr. 2024 · Due to the detection of fipronil residues in eggs, the presence of pesticides ranked as the number two hazard among products from member countries. These traces of fipronil were introduced due to its misuse as a veterinary pharmaceutical product or biocide. In 2017, Belgium informed the RASFF that laying hen farms in their country had been ...
