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24. Feb. 2023 · Der Ras/Raf/MAPK-Signalweg oder MAP-Kinase-Weg ist eine wichtige Signaltransduktionskaskade, die durch das aktivierte G-Protein Ras initiiert wird.
- Utku Bayram
RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction.
Bei den Raf-Proteinen handelt es sich um eine Familie von Proteinkinasen, welche die Isoformen A-Raf, B-Raf und C-Raf umfasst und zu den Serin/Threonin-Proteinkinasen der heterogenen Klasse EC 2.7.11.1 gehört. Sie spielen eine wichtige Rolle im MAP-Kinase-Signalweg und Ras-Raf-Signalweg.
Raf-Kinasen, Bezeichnung für cytosolische Serin-Threonin-Kinasen (Proteinkinasen) mit zentraler Funktion in der Transduktion von Wachstumsfaktor-vermittelten Signalen von der Plasma-Membran in den Zellkern. 3 Gene codieren für 3 verschiedene Raf-Kinasen: c-Raf-1, A-Raf und B-Raf, deren relative Molekülmassen zwischen 70.000 und 75.000 liegen ...
Function of Raf family kinases has been shown to play a role during organism development, cell cycle regulation, cell proliferation and differentiation, cell survival and apoptosis and many other cellular and physiological processes.
- Deborah T. Leicht, Vitaly Balan, Alexander Kaplun, Vinita Singh-Gupta, Ludmila Kaplun, Melissa Dobso...
- 10.1016/j.bbamcr.2007.05.001
- 2007
- 2007/08
16. Mai 2011 · Raf are conserved, ubiquitous serine/protein kinases discovered as the cellular elements hijacked by transforming retroviruses. The three mammalian RAF proteins (A, B and CRAF) can be activated...
18. Dez. 2023 · RAF kinase is a primary mediator of the MAPK pathway, responsible for the sequential activation of downstream targets, such as MEK and the transcription factor ERK, which control numerous...