Suchergebnisse
Suchergebnisse:
Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K 2P 18.1 is a potassium channel containing two pore-forming P domains. [5] A flaw in this gene could help trigger migraine headaches.
5. Nov. 2014 · Abstract. TWIK-related spinal cord K + channel (TRESK) is the gene product of KCNK18, the last discovered leak potassium K 2P channel gene. Under resting conditions, TRESK is constitutively phosphorylated at two regulatory regions. Protein kinase A (PKA) and microtubule affinity-regulating (MARK) kinases can be applied in experiments ...
- Péter Enyedi, Gábor Czirják
- 2015
23. Juli 2020 · Abstract. TRESK belongs to the K 2P family of potassium channels, also known as background or leak potassium channels due to their biophysical properties and their role regulating membrane potential of cells. Several studies to date have highlighted the role of TRESK in regulating the excitability of specific subtypes of sensory neurons.
- Alba Andres-Bilbe, Aida Castellanos, Anna Pujol-Coma, Gerard Callejo, Nuria Comes, Xavier Gasull
- 10.3390/ijms21155206
- 2020
- Int J Mol Sci. 2020 Aug; 21(15): 5206.
28. Apr. 2012 · TRESK is a K2P potassium channel regulated by cytoplasmic Ca 2+ concentration. The calcium/calmodulin-regulated phosphatase calcineurin activates the channel. TRESK is primarily expressed in the sensory neurons of DRG and trigeminal ganglia. Dominant negative mutation of the human channel is linked to migraine with aura. TRESK has a ro...
- Péter Enyedi, Gabriella Braun, Gábor Czirják
- 2012
14. Sept. 2020 · Tresk was expressed uniformly across the majority of SCN neurons (Supplementary Fig. 1a–c) with a similar number of Tresk mRNA puncta in the dorsal and ventral regions (Supplementary Fig. 1d; 6. ...
- Tatjana Lalic, Aiste Steponenaite, Liting Wei, Sridhar R. Vasudevan, Alistair Mathie, Stuart N. Peir...
- 2020
25. Nov. 2022 · The TWIK-related spinal cord K + channel (TRESK) is part of the two-pore domain K + channel family (K 2P ), which are also called leak potassium channels. As indicated by the channel family name, TRESK conducts K + ions along the concentration gradient in a nea …
14. Sept. 2020 · from ScienceDaily. Research has found that TRESK, a calcium regulated two-pore potassium channel, regulates the brain's central circadian clock to differentiate behavior between day and night.
