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  1. 9. Apr. 1999 · CHAPTER 1. The Role of Protective Groups in Organic Synthesis (Pages: 1-16) Summary. PDF. Request permissions. CHAPTER 2. Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols (Pages: 17-245) Summary. PDF. Request permissions. CHAPTER 3. Protection for Phenols and Catechols (Pages: 246-292) Summary. PDF. Request permissions. CHAPTER 4.

  2. 10. Apr. 2006 · The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence.

  3. A protective group (also referred to as "protecting group") is a reversably formed derivative of an existing functional group in a molecule. The protective group is temporarily attached to decrease reactivity so that the protected functional group does not react under synthetic conditions to which the molecule is subjected in one or more ...

  4. Acetyl (Ac) group is common in oligonucleotide synthesis for protection of N4 in cytosine and N6 in adenine nucleic bases and is removed by treatment with a base, most often, with aqueous or gaseous ammonia or methylamine. Ac is too stable to be readily removed from aliphatic amides.

  5. Tactical considerations to consider for each protecting group selected in a synthesis: It should be easily and efficiently introduced. It should be cheap and readily available.

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  6. 11. Aug. 2014 · Three selective methods to remove protective groups have received attention: “assisted,” electrolytic, and photolytic removal. A few additional protective groups were used for “end group” protection in the synthesis and sequential coupling of the eight different segments.

  7. 1. Nov. 2017 · Recent advances include the use of photo-sensitive and metal­ ion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protec­ tion during the solid-phase synthesis of peptides and poly­ nucleotides.