Suchergebnisse
Suchergebnisse:
Learn what protecting groups are, how they are used to decrease reactivity of functional groups, and how to choose and remove them. Find stability data, examples, and orthogonal protecting group strategies.
- Amino
T. W. Green, P. G. M. Wuts, Protective Groups in Organic...
- Tert -Butyl Ethers
Protection. An eco-compatible method for the formation of...
- Carboxyl
T. W. Green, P. G. M. Wuts, Protective Groups in Organic...
- Allyl Ether
Conversion of Allyl Ethers. Claisen Rearrangement...
- TBDMS Ethers
General. Trimethylsilyl ethers are too susceptible to...
- N-Cbz Protected Amines
Protection of Amino Groups. Amino groups are selectively...
- Methyl Ester
Protection. A convenient and efficient sonochemical method...
- Pivalic Acid Ester
Pivalic acid esters. Pv-OR, Pivalate ester, Pivalates. T. W....
- Amino
Hydroxyl (OH) ( OH) protecting groups in Organic Synthesis. Protection of alcohols: Acetyl (Ac) ( Ac) – Removed by acid or base. Benzoyl (Bz) ( Bz) – Removed by acid or base, more stable than Ac Ac group. Benzyl ( Bn Bn, Bnl Bnl) – Removed by hydrogenolysis. Bn Bn group is widely used in sugar and nucleoside chemistry.
A protecting group or protective group is introduced into a molecule by chemical modification of a functional group to obtain chemoselectivity in a subsequent chemical reaction. It plays an important role in multistep organic synthesis.
This concept can be extended to any number of functional groups. Amines can be protected by Boc-, Fmoc-, Cbz-, or Alloc protecting groups, which are removed by acids, bases, hydrogenolysis, or the use of transition metals respectively. Each group remains intact under the other reaction conditions.
Learn how to use protecting groups to prevent unwanted reactions to functional groups in organic molecules. Explore different types of protecting groups for alcohols, amines, and carbonyls, and how they add and remove in high yield.
• Which groups need protection? If R contains NH 2, OH, SH, COOH or other reactive functionalities Review: Albericio et al., Chem. Rev., 2009, 109, 2455 2. α‐Amine PGs Most common Introduction Fmoc‐Cl Boc 2 O Removal Piperidine TFA Stable Acidic co ...
10. Apr. 2006 · The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998 ...
