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13. Jan. 2022 · 1 Definition. 2 Erweiterung. 3 Bewertung. 4 Literatur. 5 Quellen. Definition. Die CRAB-Kriterien werden bei der Diagnostik einer monoklonalen Gammopathie erhoben, um den Schweregrad bzw. das Progressionsrisiko zu definieren und Organschädigungen zu erkennen. Das Akronym CRAB steht für: Erweiterung.
- Making The Diagnosis of Multiple Myeloma
- The New Definition of Active Multiple Myeloma Is
- Original Crab Criteria For The Diagnosis of Multiple Myeloma
- Recommended Exam, Tests, and Imaging Studies For The Diagnosis of Myeloma
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Unlike many cancers, the diagnosis of active myeloma that requires therapy is based upon a combination of factors. A bone marrow biopsy (or biopsy from a tissue site where myeloma may have spread) is an essential part of the diagnosis. If the percentage of plasma cells is high, e.g. > 60%, the diagnosis of active myeloma is highly likely and part o...
Clonal bone marrow plasma cells >10% or biopsy-proven bony or extramedullary plasmacytoma and any one or more of the following CRAB features and myeloma-defining events:
Evidence of end organ damage that can be attributed to the underlying plasma cell proliferative disorder, specifically:
1. History and Physical Examination See Palumbo, A. et. al Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group. 2. Routine Laboratory Testing 1. Tests to assess blood cells, including a Complete Blood Count 2. Tests to assess kidney function, including serum creatinine, creatinine clearance, ...
The IMWG criteria are a set of criteria for the diagnosis of multiple myeloma based on bone marrow biopsy, plasma cells, end-organ damage, and other factors. They include the classic CRAB criteria (hypercalcemia, renal insufficiency, anemia, and bone lesions) and three myeloma-defining events (sclerotic bone lesions, Castleman's disease, and VEGFA). The criteria allow for treatment of patients who are at high risk of progression to symptomatic disease.
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Tabelle 7: Kriterien zur Einleitung einer Therapie [IMWG, 2014; SLiM-CRAB Kriterien] Kriterium. Definition. CRAB. Hyperkalzämie (C) Calcium >2,75 mmol/l (>10,5 mg/dl) oder >0,25 mmol/l oberhalb des oberen Normwertes. Niereninsuffizienz (R) Kreatinin ≥2,0 mg/dl (>173 µmol/l) oder GFR <40ml/min. Anämie (A)
CRAB-/SLiM-Kriterien. Als Grundlage der Therapieindikation werden die SLiM-CRAB-Kriterien der IMWG verwendet: Diese beinhalten eine Plasmazellinfiltration von mehr als 10% und einer der folgenden Punkte: erhöhter Serum Kalzium Spiegel (Calcium): >0,25 mmol/l oberhalb des oberen Normwertes oder >2,75 mmol/l.
Die CRAB-Kriterien sind Bestandteil der Diagnostik des multiplen Myeloms. [1] . Definiert sind sie wie folgt: Dabei steht CRAB als Akronym für: C: hyperCalcaemia, Hyperkalzämie mit einem Serumkalziumwert von > 2,75 mmol/l oder > 0,25 mmol/l oberhalb des oberen Normwertes.
19. Mai 2016 · The diagnosis of MM requires 10% or more clonal plasma cells on bone marrow examination or a biopsy-proven plasmacytoma plus the presence of one or more myeloma-defining events. 10 Myeloma-defining events include the presence of one or more CRAB features, or one or more biomarkers of malignancy.
This International Myeloma Working Group consensus updates the disease definition of multiple myeloma to include validated biomarkers in addition to existing requirements of attributable CRAB features (hypercalcaemia, renal failure, anaemia, and bone lesions).
