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19. Okt. 2022 · Epidemiology. Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the central nervous system (CNS), caused by the human polyoma virus JC virus (JCV) and characterized by focal demyelination. 1,2 JCV has a worldwide distribution, and 20% to 70% of people exhibit serologic evidence of exposure by their late teens or as adults. 3-7 Primary JCV infection usually ...
28. Nov. 2023 · Progressive multifocal leukoencephalopathy (PML) is a disease of the white matter of the brain, caused by a virus infection (polyomavirus JC) that targets cells that make myelin—the material that insulates nerve cells (neurons). Polyomavirus JC (often called JC virus) is carried by a majority of people and is harmless except among those with lowered immune defenses.
23. Aug. 2022 · The JC virus, or John Cunningham virus, is a common germ. More than half of all adults have been exposed to it. It doesn't cause problems for most people, but it can be dangerous if you have a weak
Eine progressive multifokale Leukenzephalopathie (PML) wird durch Reaktivierung des JC-Virus verursacht. Die Krankheit tritt in der Regel bei Patienten mit eingeschränkter zellvermittelter Immunität auf, insbesondere bei Patienten mit HIV-Infektion. PML führt zu einer subakuten und progressiven Demyelinisierung im Zentralnervensystem (ZNS ...
21. Mai 2012 · Neben einer Infektion mit dem JC-Virus, dem Auslöser der PML, gehören auch eine frühere Therapie mit Immunsuppressiva und eine längere Behandlungsdauer mit Natalizumab zu den Risikofaktoren ...
Summary. Progressive multifocal encephalopathy (PML) is a fatal demyelinating disease of the central nervous system (CNS), caused by the lytic infection of oligodendrocytes by a human polyomavirus, JC virus (JCV). PML is rare disease but mostly develops in patients with underlying immunosuppressive conditions, including Hodgkin’s lymphoma ...
9. Mai 2023 · JC virus encephalopathy. infection of cortical pyramidal neurons. JC virus meningitis. infection of the meninges and choroid plexus. History and etymology The virus was first described by Åström et al. in 1958 2, and was first isolated in 1971 by Padgett et al. The latter group assigned the name of the patient to the virus which would ...
