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1. www.solvobiotech.com › transporters › mate1MATE1 - Transporters - Solvo Biotechnology

   www.solvobiotech.com › transporters › mate1

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   MATE1 (multidrug and toxin extrusion 1) Aliases: none Gene name: Solute carrier family 47 member 1 (SLC47A1) Summary. MATE1 is an apically expressed poly-specific proton antiporter which mediates the efflux of diverse substrates, primarily organic cations, in the kidney and the liver. Following its relatively recent discovery, MATE1 has rapidly ...

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     dogSglt2 is the ortholog of human SGLT2 and available in...

2. en.wikipedia.org › wiki › Multidrug_and_toxin_extrusion_protein_1Multidrug and toxin extrusion protein 1 - Wikipedia

   en.wikipedia.org › wiki › Multidrug_and_toxin_extrusion_protein_1

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   Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE (multidrug and toxic compound extrusion) family of transporters that are found in bacteria, archaea and eukaryotes.

   • Aliases: SLC47A1, MATE1, solute carrier family 47 member 1

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4. www.nature.com › articles › s41598/018/25139-8Contribution of multidrug and toxin extrusion protein 1 (MATE1)...

   www.nature.com › articles › s41598/018/25139-8

   27. Apr. 2018 · HEK293 cells stably expressing OCT2 (HEK-OCT2) or MATE1 (HEK-MATE1) were used for uptake studies. Transcellular transport of TMAO was investigated using monolayers of MDCK control cells...

5. journals.physiology.org › doi › fullWide variety of locations for rodent MATE1, a transporter protein...

   journals.physiology.org › doi › full

   1. Okt. 2006 · Human MATE1 (hMATE1) is predominantly expressed in kidney and liver. When expressed in HEK-293 cells, hMATE1 is localized in the plasma membrane and mediates electroneutral H + /tetraethylammonium (TEA) and H + /1,4-methylphenylpyridinium (MPP) exchange.

6. www.nature.com › articles › bcj201679MATE1 regulates cellular uptake and sensitivity to imatinib in...

   www.nature.com › articles › bcj201679

   16. Sept. 2016 · Here we found that the multidrug and toxin extrusion protein 1 (MATE1) transports imatinib with a manifold higher affinity. MATE1 mainly mediates the cellular uptake of imatinib into targeted...

7. pubmed.ncbi.nlm.nih.gov › 22149660Interaction of human multidrug and toxin extrusion 1 (MATE1 ... -...

   pubmed.ncbi.nlm.nih.gov › 22149660

   MATE1 is highly expressed in the kidney, liver, skeletal muscle and also in adrenal glands, testes and heart. MATE1 exchanges organic cations against protons both in influx as well as in efflux modes. Methods: Here, we examined the interaction of 25 antineoplastic agents with human MATE1.

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9. www.nature.com › articles › jhg20081Identification of multidrug and toxin extrusion (MATE1 and ... -...

   www.nature.com › articles › jhg20081

   9. Jan. 2009 · H+/organic cation antiporters (multidrug and toxin extrusion: MATE1 and MATE2-K) play important roles in the renal tubular secretion of cationic drugs. We have recently identified a regulatory ...