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1. en.wikipedia.org › wiki › Raf_kinaseRAF kinase - Wikipedia

   en.wikipedia.org › wiki › Raf_kinase

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   RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for Rapidly Accelerated Fibrosarcoma.

2. de.wikipedia.org › wiki › Raf_(Protein)Raf (Protein) – Wikipedia

   de.wikipedia.org › wiki › Raf_(Protein)

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   Bei den Raf-Proteinen handelt es sich um eine Familie von Proteinkinasen, welche die Isoformen A-Raf, B-Raf und C-Raf umfasst und zu den Serin/Threonin-Proteinkinasen der heterogenen Klasse EC 2.7.11.1 gehört. Sie spielen eine wichtige Rolle im MAP-Kinase-Signalweg und Ras-Raf-Signalweg.

   • Kofaktor: 2 Zn²⁺
   • Reaktionsart: Phosphorylierung

   • Masse/Länge Primärstruktur: 606/765/648 Aminosäuren (A-Raf/B-Raf/C-Raf)
   • Substrat: ATP + Protein

3. Videos

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     MAPK/ERK Signaling Pathway

     9. Juli 2018

     172.3K Aufrufe

   • 3:28

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     MAP Kinase Pathway (MAPK) with RAF, MEK and ERK

     1. Mai 2020

     26.2K Aufrufe

   • 6:10

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     Ras Raf MEK ERK Signaling Pathway - Overview, Regulation and Role in Pathology

     9. März 2017

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4. flexikon.doccheck.com › de › RasRas/Raf/MAPK-Signalweg - DocCheck Flexikon

   flexikon.doccheck.com › de › Ras

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   24. Feb. 2023 · 1 Definition. 2 Hintergrund. 3 Ablauf am Beispiel des EGF-Rezeptors. 3.1 Aktivierung des Ras-Proteins. 3.2 Aktivierung von Raf (MAP3K) 3.3 Aktivierung von MEK (MAP2K) 3.4 Aktivierung der MAP-Kinase (MAPK) 4 Effekt. 5 Klinische Relevanz. 5.1 Onkogenes Potential. 5.2 Entwicklungsstörungen. Definition.

   • Autor: Utku Bayram

5. www.ncbi.nlm.nih.gov › pmc › articlesRaf Kinases: Function, Regulation and Role in Human Cancer

   www.ncbi.nlm.nih.gov › pmc › articles

   Function of Raf family kinases has been shown to play a role during organism development, cell cycle regulation, cell proliferation and differentiation, cell survival and apoptosis and many other cellular and physiological processes.

   • Autor: Deborah T. Leicht, Vitaly Balan, Alexander Kaplun, Vinita Singh-Gupta, Ludmila Kaplun, Melissa Dobso...
   • DOI: 10.1016/j.bbamcr.2007.05.001

   • Publish Year: 2007
   • Veröffentlicht: 2007/08

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7. www.nature.com › articles › onc2011160Raf kinases in cancer–roles and therapeutic opportunities

   www.nature.com › articles › onc2011160

   16. Mai 2011 · Raf are conserved, ubiquitous serine/protein kinases discovered as the cellular elements hijacked by transforming retroviruses. The three mammalian RAF proteins (A, B and CRAF) can be activated...

   • Autor: G Maurer, B Tarkowski, M Baccarini

   • Publish Year: 2011

8. www.nature.com › articles › s41392/023/01705-zTargeting the RAS/RAF/MAPK pathway for cancer therapy: from ... -...

   www.nature.com › articles › s41392/023/01705-z

   18. Dez. 2023 · RAF kinase is a primary mediator of the MAPK pathway, responsible for the sequential activation of downstream targets, such as MEK and the transcription factor ERK, which control numerous...

9. www.nature.com › articles › s41568/023/00650-xThe role of CRAF in cancer progression: from molecular ... -...

   www.nature.com › articles › s41568/023/00650-x

   9. Jan. 2024 · The RAF family of kinases includes key activators of the pro-tumourigenic mitogen-activated protein kinase pathway. Hyperactivation of RAF proteins, particularly BRAF and CRAF, drives tumour...