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    AnzeigeC-Raf Kinase Assay Kit - BPS Bioscience - Biomol.de

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  1. en.wikipedia.org › wiki › Raf_kinaseRAF kinase - Wikipedia

    RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for Rapidly Accelerated Fibrosarcoma.

  2. de.wikipedia.org › wiki › Raf_(Protein)Raf (Protein) – Wikipedia

    Bei den Raf-Proteinen handelt es sich um eine Familie von Proteinkinasen, welche die Isoformen A-Raf, B-Raf und C-Raf umfasst und zu den Serin/Threonin-Proteinkinasen der heterogenen Klasse EC 2.7.11.1 gehört. Sie spielen eine wichtige Rolle im MAP-Kinase-Signalweg und Ras-Raf-Signalweg.

    • 2 Zn²⁺
    • Phosphorylierung
    • 606/765/648 Aminosäuren (A-Raf/B-Raf/C-Raf)
    • ATP + Protein

  3. Videos

    Alle anzeigen

  4. flexikon.doccheck.com › de › RasRas/Raf/MAPK-Signalweg - DocCheck Flexikon

    24. Feb. 2023 · 1 Definition. 2 Hintergrund. 3 Ablauf am Beispiel des EGF-Rezeptors. 3.1 Aktivierung des Ras-Proteins. 3.2 Aktivierung von Raf (MAP3K) 3.3 Aktivierung von MEK (MAP2K) 3.4 Aktivierung der MAP-Kinase (MAPK) 4 Effekt. 5 Klinische Relevanz. 5.1 Onkogenes Potential. 5.2 Entwicklungsstörungen. Definition.

    • Utku Bayram

  5. www.ncbi.nlm.nih.gov › pmc › articlesRaf Kinases: Function, Regulation and Role in Human Cancer

    Function of Raf family kinases has been shown to play a role during organism development, cell cycle regulation, cell proliferation and differentiation, cell survival and apoptosis and many other cellular and physiological processes.

    • Deborah T. Leicht, Vitaly Balan, Alexander Kaplun, Vinita Singh-Gupta, Ludmila Kaplun, Melissa Dobso...
    • 10.1016/j.bbamcr.2007.05.001
    • 2007
    • 2007/08

  6. Bilder

    • Cellular functions of RAF kinases.RAS mediates the activation of A-RAF ...
    • PDB-101: Molecule of the Month: RAF Protein Kinases
    • 5 Ras/Raf/MAP kinase signalling pathway (Wong and Ng 2008 ...
    • Raf domain structure and protein interactions. (A) The Raf kinases can ...
    • Structure of WT B-RAF Kinase Domain (A) Ribbons diagram of WT B-RAF ...

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  7. www.nature.com › articles › onc2011160Raf kinases in cancer–roles and therapeutic opportunities

    16. Mai 2011 · Raf are conserved, ubiquitous serine/protein kinases discovered as the cellular elements hijacked by transforming retroviruses. The three mammalian RAF proteins (A, B and CRAF) can be activated...

    • G Maurer, B Tarkowski, M Baccarini
    • 2011

  8. www.nature.com › articles › s41392/023/01705-zTargeting the RAS/RAF/MAPK pathway for cancer therapy: from ... -...

    18. Dez. 2023 · RAF kinase is a primary mediator of the MAPK pathway, responsible for the sequential activation of downstream targets, such as MEK and the transcription factor ERK, which control numerous...

  9. www.nature.com › articles › nrm3979Regulation of RAF protein kinases in ERK signalling - Nature

    23. Apr. 2015 · The three cellular RAF family kinases (ARAF, BRAF and CRAF) were identified 30 years ago on the basis of their homology to the viral oncoprotein v-raf. They were then found to be core members...